ArticleCritical care (London, England)2012
Influence of respiratory rate and end-expiratory pressure variation on cyclic alveolar recruitment in an experimental lung injury model.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Dexmedetomidine reduces ventilator-induced lung injury via ERK1/2 pathway activation.Molecular medicine reports · 2020Article
- POCritical care (London, England) · 2019Article
- Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome.Journal of visualized experiments : JoVE · 2018Article
- Detection of inspiratory recruitment of atelectasis by automated lung sound analysis as compared to four-dimensional computed tomography in a porcine lung injury model.Critical care (London, England) · 2018Article
- Respiratory oscillations in alveolar oxygen tension measured in arterial blood.Scientific reports · 2017Article
- Cyclic PaOBMC anesthesiology · 2017Article
- Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs.Respiratory research · 2017Article
- Experimental investigation of the effect of polymer matrices on polymer fibre optic oxygen sensors and their time response characteristics using a vacuum testing chamber and a liquid flow apparatus.Sensors and actuators. B, Chemical · 2016Article
- Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome.British journal of anaesthesia · 2015Article
- Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model.BMC pulmonary medicine · 2015Article
- Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs.Respiratory research · 2014Article
- A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro.Respiratory physiology & neurobiology · 2014Article
- TIP peptide inhalation in experimental acute lung injury: effect of repetitive dosage and different synthetic variants.BMC anesthesiology · 2014Article
- Year in review 2012: Critical Care--Respirology.Critical care (London, England) · 2013Review
- TIP peptide inhalation in oleic acid-induced experimental lung injury: a post-hoc comparison.BMC research notes · 2013Article
- Correlation of thermodilution-derived extravascular lung water and ventilation/perfusion-compartments in a porcine model.Intensive care medicine · 2013Article
- Article
- Influences of assisted breathing and mechanical ventilator settings on tidal volume and alveolar pressures in acute respiratory distress syndrome: a bench study.Revista Brasileira de terapia intensivaArticle
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCyclic alveolar recruitment/derecruitment (R/D) is an important mechanism of ventilator-associated lung injury. In experimental models this process can be measured with high temporal resolution by detection of respiratory-dependent oscillations of the paO2 (ΔpaO2). A previous study showed that end-expiratory collapse can be prevented by an increased respiratory rate in saline-lavaged rabbits. The current study compares the effects of increased positive end-expiratory pressure (PEEP) versus an individually titrated respiratory rate (RRind) on intra-tidal amplitude of Δ paO2 and on average paO2 in saline-lavaged pigs.
methodsAcute lung injury was induced by bronchoalveolar lavage in 16 anaesthetized pigs. R/D was induced and measured by a fast-responding intra-aortic probe measuring paO2. Ventilatory interventions (RRind (n=8) versus extrinsic PEEP (n=8)) were applied for 30 minutes to reduce Δ paO2. Haemodynamics, spirometry and Δ paO2 were monitored and the Ventilation/Perfusion distributions were assessed by multiple inert gas elimination. The main endpoints average and Δ paO2 following the interventions were analysed by Mann-Whitney-U-Test and Bonferroni's correction. The secondary parameters were tested in an explorative manner.
resultsBoth interventions reduced Δ paO2. In the RRind group, ΔpaO2 was significantly smaller (P<0.001). The average paO2 continuously decreased following RRind and was significantly higher in the PEEP group (P<0.001). A sustained difference of the ventilation/perfusion distribution and shunt fractions confirms these findings. The RRind application required less vasopressor administration.
conclusionsDifferent recruitment kinetics were found compared to previous small animal models and these differences were primarily determined by kinetics of end-expiratory collapse. In this porcine model, respiratory rate and increased PEEP were both effective in reducing the amplitude of paO2 oscillations. In contrast to a recent study in a small animal model, however, increased respiratory rate did not maintain end-expiratory recruitment and ultimately resulted in reduced average paO2 and increased shunt fraction.
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