ArticleDiabetes & metabolism journal2011
The Relationship among Homocysteine, Bilirubin, and Diabetic Retinopathy.
Article in Diabetes & metabolism journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- The Negative Relationship between Bilirubin Level and Diabetic Retinopathy: A Meta-Analysis.PloS one · 2016Pooled it
- Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis.Diagnostic pathology · 2014Pooled it
- Homocysteine serum levels in diabetic patients with non proliferative, proliferative and without retinopathy.BioMed research international · 2014Trial
- Association between serum bilirubin and diabetic retinopathy: results from the NHANES 1999-2018 and Mendelian randomization study.Diabetology & metabolic syndrome · 2026Article
- Elevated homocysteine levels are associated with increased diabetes risk in patients with hypertension: a multicenter longitudinal study.Frontiers in cardiovascular medicine · 2026Article
- Correlation of diabetic retinopathy with oxidative biomarkers among diabetic patients.Bioinformation · 2025Article
- cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy.Investigative ophthalmology & visual science · 2024Article
- Blood Viscosity in Subjects With Type 2 Diabetes Mellitus: Roles of Hyperglycemia and Elevated Plasma Fibrinogen.Frontiers in physiology · 2022Article
- Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age-Related Cataract by Regulating NF-Oxidative medicine and cellular longevity · 2022Article
- Quantifying Fibrinogen-Dependent Aggregation of Red Blood Cells in Type 2 Diabetes Mellitus.Biophysical journal · 2020Article
- A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes.Molecular vision · 2020Article
- The MTHFR C677T polymorphism influences the efficacy of folic acid supplementation on the nerve conduction studies in patients with diabetic polyneuropathy; A randomized, double blind, placebo-controlled study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- Serum bilirubin levels are negatively associated with diabetic retinopathy in patients with type 1 diabetes and normal renal function.International ophthalmology · 2018Article
- Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population.International journal of endocrinology · 2018Article
- The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes.International journal of endocrinology · 2018Article
- Inverse Association between Serum Bilirubin Levels and Retinopathy in Patients with Type 2 Diabetes Mellitus.Journal of clinical and diagnostic research : JCDR · 2017Article
- Homocysteine and Its Relationship to Asymptomatic Carotid Stenosis in a Chinese Community Population.Scientific reports · 2016Article
- Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology.Journal of diabetes research · 2016Review
- Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia.The American journal of pathology · 2014Article
- Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease.Cardiovascular diabetology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic retinopathy is a common microvascular complication of diabetes mellitus (DM) and the leading cause of blindness in adults. Homocysteine, a risk factor with toxic effects on vascular endothelial cells, and bilirubin, a protectant with antioxidant and anti-inflammatory properties on the vasculature, have been reported to be linked to vaso-occlusive disorders. Therefore, the author of the present study investigated the association between the levels of plasma homocysteine and serum total bilirubin and the incidence of diabetic retinopathy as a chronic microvascular complication in patients with type 2 diabetes mellitus (T2DM).
methodsA total of 102 patients with T2DM who visited our hospital from January 2009 to January 2010 were assessed.
resultsOf the 102 patients, the prevalence of diabetic retinopathy was 67 cases (65.7%) according to clinical ophthalmic examination. The duration of DM (P<0.001), age (P=0.003), fasting blood glucose (P=0.045) and urine albumin-creatinine ratio (P=0.015) in univariate analysis and plasma homocysteine level (P=0.038), duration of DM (P=0.001), and total bilirubin level (P=0.012) in multiple logistic regression analysis were statistically significantly associated with the incidence of diabetic retinopathy.
conclusionThe present study indicates that homocysteine and bilirubin may be useful biomarkers for increased risk of diabetic retinopathy since retinopathy in patients with T2DM was linked to higher plasma homocysteine level and decreased serum total bilirubin level.
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