ArticlePloS one2012
Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity.Frontiers in immunology · 2024Article
- Small-molecule TIP60 inhibitors enhance regulatory T cell induction through TIP60-P300 acetylation crosstalk.iScience · 2023Article
- Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.Immunity · 2022Article
- The Importance of the Transcription Factor Foxp3 in the Development of Primary Immunodeficiencies.Journal of clinical medicine · 2022Review
- Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations.Nucleic acids research · 2021Review
- HDAC10 deletion promotes Foxp3Scientific reports · 2020Article
- Sirtuin-1 in immunotherapy: A Janus-headed target.Journal of leukocyte biology · 2019Review
- Article
- Loss of HDAC6 alters gut microbiota and worsens obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- How little is known about the role of human FOXP3+ Tregs in tumors.Expert opinion on therapeutic targets · 2018Article
- Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Review
- FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Regulatory T cells: tolerance induction in solid organ transplantation.Clinical and experimental immunology · 2017Review
- Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.Cell metabolism · 2017Article
- Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.EBioMedicine · 2016Article
- HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells.International journal of cancer · 2016Article
- Targeting Sirtuin-1 prolongs murine renal allograft survival and function.Kidney international · 2016Article
- Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation.Frontiers in immunology · 2015Review
- Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.Molecular and cellular biology · 2014Article
- Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.Mucosal immunology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe forkhead box transcription factor, Foxp3, is master regulator of the development and function of CD4+CD25+ T regulatory (Treg) cells that limit autoimmunity and maintain immune homeostasis. The carboxyl-terminal forkhead (FKH) domain is required for the nuclear localization and DNA binding of Foxp3. We assessed how individual FKH lysines contribute to the functions of Foxp3 in Treg cells. METHODOLOGY/PRINCIPAL
findingsWe found that mutation of FKH lysines at position 382 (K17) and at position 393 (K18) impaired Foxp3 DNA binding and inhibited Treg suppressive function in vivo and in vitro. These lysine mutations did not affect the level of expression of Foxp3 but inhibited IL-2 promoter remodeling and had important and differing effects on Treg-associated gene expression. CONCLUSIONS/SIGNIFICANCE: These data point to complex effects of post-translational modifications at individual lysines within the Foxp3 FKH domain that affect Treg function. Modulation of these events using small molecule inhibitors may allow regulation of Foxp3+ Treg function clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.