Trial reportMedical decision making : an international journal of the Society for Medical Decision Making
Impact of literacy and numeracy on motivation for behavior change after diabetes genetic risk testing.
Trial report in Medical decision making : an international journal of the Society for Medical Decision Making. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04331535 (Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of communicating the genetic risk of cardiometabolic disorders on motivation and actual engagement in preventative lifestyle modification and clinical outcome: a systematic review and meta-analysis of randomised controlled trials.The British journal of nutrition · 2016Pooled it
- Outcomes of a Randomized Controlled Trial of Genomic Counseling for Patients Receiving Personalized and Actionable Complex Disease Reports.Journal of genetic counseling · 2017Trial
- A randomized trial Examining The Impact Of Communicating Genetic And Lifestyle Risks For Obesity.Obesity (Silver Spring, Md.) · 2016Trial
- Genetic literacy and patient perceptions of IBD testing utility and disease control: a randomized vignette study of genetic testing.Inflammatory bowel diseases · 2014Trial
- Awareness of Genetic Testing and Its Impact on Changing Behavior among General Population of the USA: Health Information National Trends Survey (HINTS 2022).Lifestyle genomics · 2025Article
- Participant-guided development of bilingual genomic educational infographics for Electronic Medical Records and Genomics Phase IV study.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Pathways linking health literacy to self-care in diabetic patients with physical disabilities: A moderated mediation model.PloS one · 2024Article
- Navigating the uncertainty of precision cancer screening: The role of shared decision-making.PEC innovation · 2023Article
- Variability in conceptualizations and measurement of genetic literacy.PEC innovation · 2023Article
- Knowledge and Attitudes About Genetic Testing Among Black and White Women with Breast Cancer.Journal of racial and ethnic health disparities · 2021Article
- GeneLiFT: A novel test to facilitate rapid screening of genetic literacy in a diverse population undergoing genetic testing.Journal of genetic counseling · 2021Article
- A scoping review of social and behavioral science research to translate genomic discoveries into population health impact.Translational behavioral medicine · 2021Article
- Comparing the effectiveness of motivational interviewing and self-development education on type II diabetes mellitus patients' lifestyle.Journal of education and health promotion · 2021Article
- Compliance with the Very Integrated Program (VIP) for Smoking Cessation, Nutrition, Physical Activity and Comorbidity Education Among Patients in Treatment for Alcohol and Drug Addiction.International journal of environmental research and public health · 2019Article
- Enhancing health literacy through co-design: development of culturally appropriate materials on genetic risk and customary consanguineous marriage.Primary health care research & development · 2019Article
- A Qualitative Study of Anticipated Decision Making around Type 2 Diabetes Genetic Testing: the Role of Scientifically Concordant and Discordant Expectations.Journal of genetic counseling · 2017Article
- Exploring Genetic Numeracy Skills in a Sample of U.S. University Students.Frontiers in public health · 2017Article
- Talking About Type 2 Diabetes: Family Communication From the Perspective of At-Risk Relatives.The Diabetes educator · 2015Article
- The Many Facets of Genetic Literacy: Assessing the Scalability of Multiple Measures for Broad Use in Survey Research.PloS one · 2015Article
- Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.The application of clinical genetics · 2015Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundType 2 diabetes genetic risk testing might motivate at-risk patients to adopt diabetes prevention behaviors. However, the influence of literacy and numeracy on patient response to diabetes genetic risk is unknown.
objectiveThe authors investigated the association of health literacy, genetic literacy, and health numeracy with patient responses to diabetes genetic risk.
designand Measurements Overweight patients at high phenotypic risk for type 2 diabetes were recruited for a clinical trial of diabetes genetic risk testing. At baseline, participants predicted how their motivation for lifestyle modification to prevent diabetes might change in response to hypothetical scenarios of receiving "high" and "low" genetic risk results. Responses were analyzed according to participants' health literacy, genetic literacy, and health numeracy.
resultsTwo-thirds (67%) of participants (n = 175) reported very high motivation to prevent diabetes. Despite high health literacy (92% at high school level), many participants had limited health numeracy (30%) and genetic literacy (38%). Almost all (98%) reported that high-risk genetic results would increase their motivation for lifestyle modification. In contrast, response to low-risk genetic results varied. Higher levels of health literacy (P = 0.04), genetic literacy (P = 0.02), and health numeracy (P = 0.02) were associated with an anticipated decrease in motivation for lifestyle modification in response to low-risk results.
conclusionsWhile patients reported that high-risk genetic results would motivate them to adopt healthy lifestyle changes, response to low-risk results varied by patient numeracy and literacy. However, anticipated responses may not correlate with true behavior change. If future research justifies the clinical use of genetic testing to motivate behavior change, it may be important to assess how patient characteristics modify that motivational effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.