ArticleEukaryotic cell2012
The Ustilago maydis Nit2 homolog regulates nitrogen utilization and is required for efficient induction of filamentous growth.
Article in Eukaryotic cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 47 citations in OpenAlex.
- Insights into the Phylogeny ofJournal of fungi (Basel, Switzerland) · 2026Article
- Online Monitoring of Oxygen Transfer Rate as a Versatile Tool for Fermentation Characterization and Optimization.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Chromosome-level comparative genomics and host-specific fungal transcriptomics uncover adaptive virulence strategies in the sugarcane smut pathogen.BMC genomics · 2025Article
- Genomic factors limiting the diversity of Saccharomycotina plant pathogens.G3 (Bethesda, Md.) · 2025Article
- Ustilago maydis Nit2 Regulates Nitrate Utilisation During Biotrophy and Affects Amino Acid Metabolism of Galls Under Nitrogen Depletion.Molecular plant pathology · 2025Article
- Proteomics ofJournal of fungi (Basel, Switzerland) · 2023Article
- A Gene fromJournal of fungi (Basel, Switzerland) · 2023Article
- The AMP-Activated Protein Kinase (AMPK) Positively Regulates Lysine Biosynthesis Induced by Citric Acid inJournal of fungi (Basel, Switzerland) · 2023Article
- Construction and analysis of gene co-expression network in the pathogenic fungusFrontiers in microbiology · 2022Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Every cloud has a silver lining: how abiotic stresses affect gene expression in plant-pathogen interactions.Journal of experimental botany · 2021Review
- Investigating the Smuts: Common Cues, Signaling Pathways, and the Role ofJournal of fungi (Basel, Switzerland) · 2020Review
- NIT2 overexpression predicts poor prognosis in tongue squamous cell carcinoma patients.Molecular biology reports · 2020Article
- A Tripartite Interaction among the BasidiomyceteThe Plant cell · 2020Article
- Growth Behavior of SelectedFrontiers in bioengineering and biotechnology · 2020Article
- New Insights of Ustilago maydis as Yeast Model for Genetic and Biotechnological Research: A Review.Current microbiology · 2019Review
- The Biotrophic Development ofThe Plant cell · 2018Article
- Strand-Specific RNA-Seq Analyses of Fruiting Body Development in Coprinopsis cinerea.PloS one · 2015Article
- Transcriptomic analysis of Ustilago maydis infecting Arabidopsis reveals important aspects of the fungus pathogenic mechanisms.Plant signaling & behavior · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrogen catabolite repression (NCR) is a regulatory strategy found in microorganisms that restricts the utilization of complex and unfavored nitrogen sources in the presence of favored nitrogen sources. In fungi, this concept has been best studied in yeasts and filamentous ascomycetes, where the GATA transcription factors Gln3p and Gat1p (in yeasts) and Nit2/AreA (in ascomycetes) constitute the main positive regulators of NCR. The reason why functional Nit2 homologs of some phytopathogenic fungi are required for full virulence in their hosts has remained elusive. We have identified the Nit2 homolog in the basidiomycetous phytopathogen Ustilago maydis and show that it is a major, but not the exclusive, positive regulator of nitrogen utilization. By transcriptome analysis of sporidia grown on artificial media devoid of favored nitrogen sources, we show that only a subset of nitrogen-responsive genes are regulated by Nit2, including the Gal4-like transcription factor Ton1 (a target of Nit2). Ustilagic acid biosynthesis is not under the control of Nit2, while nitrogen starvation-induced filamentous growth is largely dependent on functional Nit2. nit2 deletion mutants show the delayed initiation of filamentous growth on maize leaves and exhibit strongly compromised virulence, demonstrating that Nit2 is required to efficiently initiate the pathogenicity program of U. maydis.
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