ArticleJournal of molecular neuroscience : MN2012
FOXJ2 expression in rat spinal cord after injury and its role in inflammation.
Article in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Foxj2 Attenuates LPS-Induced Inflammatory Response in Macrophages.Mediators of inflammation · 2025Article
- H3K4me3-Mediated FOXJ2/SLAMF8 Axis Aggravates Thrombosis and Inflammation in β2GPI/Anti-β2GPI-Treated Monocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis.Cell & bioscience · 2021Article
- miR-20a/Foxj2 Axis Mediates Growth and Metastasis of Colorectal Cancer Cells as Identified by Integrated Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Expression Profiles of Long Noncoding RNAs in Intranasal LPS-Mediated Alzheimer's Disease Model in Mice.BioMed research international · 2019Article
- Expression of Dixdc1 and its Role in Astrocyte Proliferation after Traumatic Brain Injury.Cellular and molecular neurobiology · 2017Article
- Article
- The prognostic role and reduced expression of FOXJ2 in human hepatocellular carcinoma.Molecular medicine reports · 2016Article
- The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation.Journal of molecular neuroscience : MN · 2014Article
- Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats.Journal of molecular neuroscience : MN · 2014Article
- The expression of FBP1 after traumatic brain injury and its role in astrocyte proliferation.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foxj2 (forkhead box J2), a novel member of the forkhead/HNF3 family, binds DNA with a dual sequence specificity. It may play a role in maintenance and survival of developing and adult neurons. However, its expression and function in the central nervous system lesion are still unclear. In this study, we performed a spinal cord injury (SCI) model in adult Sprague-Dawley rats and investigated the dynamic changes of Foxj2 expression in the spinal cord. Western blot analysis revealed that Foxj2 was present in normal spinal cord. It gradually increased, reached a peak at day 5 after SCI, and then declined during the following days. Double immunofluorescence staining revealed wide expression of Foxj2, which is detected in neurons and astrocytes. After injury, Foxj2 expression was increased predominantly in astrocytes, which highly expressed proliferating cell nuclear antigen, a marker for proliferating cells. And knockdown of Foxj2 in cultured primary astrocytes by siRNA showed that Foxj2 played an important role in lipopolysaccharide-induced inflammatory responses. These results suggested that Foxj2 may be involved in the pathophysiology of SCI, and further research is needed to have a good understanding of its function and mechanism.
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