ArticleLasers in surgery and medicine2012
Combined two-photon luminescence microscopy and OCT for macrophage detection in the hypercholesterolemic rabbit aorta using plasmonic gold nanorose.
Article in Lasers in surgery and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Label-free imaging of atherosclerotic plaques using third-harmonic generation microscopy.Biomedical optics express · 2018Article
- Dual-modality fiber-based OCT-TPL imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques.Biomedical optics express · 2015Article
- Macrophages and intravascular OCT bright spots: a quantitative study.JACC. Cardiovascular imaging · 2015Article
- Parallel synthesis of poly(amino ether)-templated plasmonic nanoparticles for transgene delivery.ACS applied materials & interfaces · 2014Article
- Two-photon luminescence properties of gold nanorods.Biomedical optics express · 2013Article
- Targeted molecular imaging of angiogenesis in PET and SPECT: a review.The Yale journal of biology and medicine · 2012Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesThe macrophage is an important early cellular marker related to risk of future rupture of atherosclerotic plaques. Two-channel two-photon luminescence (TPL) microscopy combined with optical coherence tomography (OCT) was used to detect, and further characterize the distribution of aorta-based macrophages using plasmonic gold nanorose as an imaging contrast agent. STUDY DESIGN/MATERIALS AND
methodsNanorose uptake by macrophages was identified by TPL microscopy in macrophage cell culture. Ex vivo aorta segments (8 × 8 × 2 mm(3) ) rich in macrophages from a rabbit model of aorta inflammation were imaged by TPL microscopy in combination with OCT. Aorta histological sections (5 µm in thickness) were also imaged by TPL microscopy.
resultsMerged two-channel TPL images showed the lateral and depth distribution of nanorose-loaded macrophages (confirmed by RAM-11 stain) and other aorta components (e.g., elastin fiber and lipid droplet), suggesting that nanorose-loaded macrophages are diffusively distributed and mostly detected superficially within 20 µm from the luminal surface of the aorta. Moreover, OCT images depicted detailed surface structure of the diseased aorta.
conclusionsResults suggest that TPL microscopy combined with OCT can simultaneously reveal macrophage distribution with respect to aorta surface structure, which has the potential to detect vulnerable plaques and monitor plaque-based macrophages overtime during cardiovascular interventions.
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