Evidence map›Paper›PMID 22246961›Full record

ArticleMycopathologia2012

Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses.

Sara Carvalhinho, Ana Margarida Costa, Ana Cláudia Coelho, Eugénio Martins, Ana Sampaio

Abstract read
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Article in Mycopathologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Microbiota and cancer: Elucidating the role ofWorld journal of clinical oncology · 2025
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  5. Prevalence and drug susceptibility of clinicalOne health (Amsterdam, Netherlands) · 2024
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  6. Life (Basel, Switzerland) · 2024
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  7. Molecules (Basel, Switzerland) · 2023
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  8. Antifungal Activity ofMolecules (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Effects of Cinnamon (Molecules (Basel, Switzerland) · 2020
    Review
  11. The Effects of Cinnamaldehyde (Cinnamon Derivatives) and Nystatin onOpen access Macedonian journal of medical sciences · 2019
    Article
  12. Article
  13. In Vitro Antifungal Susceptibility ofBioMed research international · 2018
    Article
  14. Review
  15. "Rhetoric to Reality"- Efficacy ofJournal of clinical and diagnostic research : JCDR · 2017
    Article
  16. Article
  17. ANTIMICROBIAL ACTIVITY OF AQUEOUS, ETHANOLIC AND METHANOLIC LEAF EXTRACTS FROMAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2016
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sara CarvalhinhoDepartment of Biology and Environment, University of Trás-os-Montes and Alto Douro (UTAD), PO Box 1013, 5001-911, Vila Real, Portugal.
Ana Margarida Costa
Ana Cláudia Coelho
Eugénio Martins
Ana Sampaio

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Forty Candida albicans strains isolated from patient's mouth with fixed orthodontic appliances were analyzed to their susceptibilities to antifungal agents, mouth rinses and essential oils. Susceptibility to fluconazole, econazole, miconazole and ketoconazole, amphotericin B and nystatin was assessed by the disk diffusion (DD) method based on the Clinical and Laboratory Standards Institute M44-A protocol, and by Etest (fluconazole and amphotericin B). The susceptibilities to mouth rinses and essential oils were also determined by the DD technique. All isolates tested were susceptible (S) to amphotericin B, nystatin and fluconazole. The overall concordance between the DD and the Etest was 100% for amphotericin and fluconazole. One isolate was resistant to econazole (2.5%) and the other to ketoconazole (2.5%). Econazole and ketoconazole had the highest percentages of susceptible dose dependent (SDD), 55 and 95%, respectively. Regarding to the susceptibility isolates profile, seven phenotypes were detected, and the 3 more represented (90% of the isolates) of them were SDD to one, two or three azoles. The study of mouth rinses showed a high variability of efficacy against C. albicans. The results showed that the isolates susceptibility to essential oils differed (P < 0.05). The profile activity was: cinnamon > laurel > mint > eucalyptus > rosemary > lemon > myrrh > tangerine. The main finding was that the susceptibility to cinnamon and laurel varied among the three more representative antifungal phenotypes (P < 0.05). The susceptibility of econazole-SDD isolates to cinnamon and lemon was higher than those of the econazole-S yeasts (P < 0.05). In contrast, econazole-SDD isolates were less affected by laurel than econazole-S counterparts (P < 0.05).

Indexed as

Antifungal AgentsAnti-Infective Agents, LocalCandida albicansHumansMicrobial Sensitivity TestsMouthOils, VolatilePlant ExtractsPlantsAntifungal AgentsAnti-Infective Agents, LocalOils, VolatilePlant Extracts

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.