ArticleMuscle & nerve2012
The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.
Article in Muscle & nerve, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Insights on Natural Products Against Amyotrophic Lateral Sclerosis (ALS).Current neuropharmacology · 2024Review
- Electrophysiological effects of BDNF and TrkB signaling at type-identified diaphragm neuromuscular junctions.Journal of neurophysiology · 2023Article
- Brain derived neurotrophic factor/tropomyosin related kinase B signaling impacts diaphragm neuromuscular transmission in a novel rat chemogenetic model.Frontiers in cellular neuroscience · 2022Article
- Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury.Journal of neurophysiology · 2021Review
- Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats.Journal of neurophysiology · 2021Article
- TrkB signaling contributes to transdiaphragmatic pressure generation in aged mice.Journal of neurophysiology · 2021Article
- Inhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review.Frontiers in physiology · 2020Review
- Diaphragm neuromuscular transmission failure in aged rats.Journal of neurophysiology · 2019Article
- Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction.Physiological reports · 2017Article
- Functional recovery after cervical spinal cord injury: Role of neurotrophin and glutamatergic signaling in phrenic motoneurons.Respiratory physiology & neurobiology · 2016Review
- Functional impact of sarcopenia in respiratory muscles.Respiratory physiology & neurobiology · 2016Review
- Role of TrkB kinase activity in aging diaphragm neuromuscular junctions.Experimental gerontology · 2015Article
- Functional impact of diaphragm muscle sarcopenia in both male and female mice.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Ageing and neurotrophic signalling effects on diaphragm neuromuscular function.The Journal of physiology · 2015Article
- TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection.Experimental neurology · 2014Article
- TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkB(F616A) mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (∽32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.