ArticleMuscle & nerve2012
Chronic nerve compression alters Schwann cell myelin architecture in a murine model.
Article in Muscle & nerve, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Computer Use and Compressive Neuropathies of the Upper Limbs: A Hidden Risk?Journal of clinical medicine · 2025Review
- Anti-Tumor Effect and Neurotoxicity of Ethanol Adjuvant Therapy after Surgery of a Soft Tissue Sarcoma.Current oncology (Toronto, Ont.) · 2023Article
- Surgically Induced Demyelination in Rat Sciatic Nerve.Brain sciences · 2023Article
- Clemastine improves electrophysiologic and histomorphometric changes through promoting myelin repair in a murine model of compression neuropathy.Scientific reports · 2021Article
- Addressing the Need of a Translational Approach in Peripheral Neuropathy Research: Morphology Meets Function.Brain sciences · 2021Article
- Effect of Electrical and Electromechanical Stimulation on PC12 Cell Proliferation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2021Article
- Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing.International journal of molecular sciences · 2020Review
- Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier.European journal of histochemistry : EJH · 2020Article
- Regenerative Injections Including 5% Dextrose and Platelet-Rich Plasma for the Treatment of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p.Theranostics · 2020Article
- Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice.Neurochemical research · 2019Article
- Mechanical changes of peripheral nerve tissue microenvironment and their structural basis during development.APL bioengineering · 2019Article
- Glial Plasticity in the Trigeminal Root Entry Zone of a Rat Trigeminal Neuralgia Animal Model.Neurochemical research · 2019Article
- Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy.The Journal of bone and joint surgery. American volume · 2019Article
- A novel chronic nerve compression model in the rat.Neural regeneration research · 2018Article
- Carpal Tunnel Syndrome and Other Entrapment Neuropathies.Oman medical journal · 2017Review
- Aortic arch compliance and idiopathic unilateral vocal fold paralysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Article
- Chronic peripheral nerve compression disrupts paranodal axoglial junctions.Muscle & nerve · 2017Article
- Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats.Journal of pain research · 2017Article
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5 authors.
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Abstract
introductionMyelinating Schwann cells compartmentalize their outermost layer to form actin-rich channels known as Cajal bands. Herein we investigate changes in Schwann cell architecture and cytoplasmic morphology in a novel mouse model of carpal tunnel syndrome.
methodsChronic nerve compression (CNC) injury was created in wild-type and slow-Wallerian degeneration (Wld(S) ) mice. Over 12 weeks, nerves were electrodiagnostically assessed, and Schwann cell morphology was thoroughly evaluated.
resultsA decline in nerve conduction velocity and increase in g-ratio is observed without early axonal damage. Schwann cells display shortened internodal lengths and severely disrupted Cajal bands. Quite surprisingly, the latter is reconstituted without improvements to nerve conduction velocity.
conclusionsChronic entrapment injuries like carpal tunnel syndrome are primarily mediated by the Schwann cell response, where decreases in internodal length and myelin thickness disrupt the efficiency of impulse propagation. Restitution of Cajal bands is not sufficient for remyelination after CNC injury.
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