ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Diverse functions of distal regulatory elements at the IFNG locus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- TIF1γ regulates stability of regulatory T cells during inflammation.Nature immunology · 2026Article
- Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements.European journal of immunology · 2026Article
- Between immunomodulation and immunotolerance: The role of IFNγ in SARS-CoV-2 disease.Cytokine · 2021Review
- In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiation.Immunological reviews · 2021Review
- Divergent lncRNAFrontiers in immunology · 2018Article
- Profiles of Long Noncoding RNAs in Human Naive and Memory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Long non-coding RNAs in innate and adaptive immunity.Virus research · 2016Review
- Long noncoding RNAs in T lymphocytes.Journal of leukocyte biology · 2016Review
- The Ly49E Receptor Inhibits the Immune Control of AcuteFrontiers in immunology · 2016Article
- Transcriptional Enhancers in the Regulation of T Cell Differentiation.Frontiers in immunology · 2015Review
- Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection.PLoS pathogens · 2014Article
- Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription.PLoS genetics · 2014Article
- Epigenetic Activation and Silencing of the Gene that Encodes IFN-γ.Frontiers in immunology · 2013Article
- Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element.Genes and immunity · 2012Article
- Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation.The Journal of experimental medicine · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have identified multiple conserved noncoding sequences (CNS) at the mouse Ifng locus sufficient for enhancer activity in cell-based assays. These studies do not directly address biology of the human IFNG locus in a genomic setting. IFNG enhancers may be functionally redundant or each may be functionally unique. We test the hypothesis that each IFNG enhancer has a unique necessary function using a bacterial artificial chromosome transgenic model. We find that CNS-30, CNS-4, and CNS+20 are required at distinct stages of Th1 differentiation, whereas CNS-16 has a repressive role in Th1 and Th2 cells. CNS+20 is required for IFN-γ expression by memory Th1 cells and NKT cells. CNS-4 is required for IFN-γ expression by effector Th1 cells. In contrast, CNS-16, CNS-4, and CNS+20 are each partially required for human IFN-γ expression by NK cells. Thus, IFNG CNS enhancers have redundant necessary functions in NK cells but unique necessary functions in Th cells. These results also demonstrate that distinct CNSs are required to transcribe IFNG at each stage of the Th1 differentiation pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.