Evidence map›Paper›PMID 22246619›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2012

Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women.

Anna H Wu, Darcy Spicer, Frank Z Stanczyk, Chiu-Chen Tseng, Chung S Yang, Malcolm C Pike

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  5. Green and black tea for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2013
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  14. Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anna H WuDepartment of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA. annawu@usc.edu
Darcy Spicer
Frank Z Stanczyk
Chiu-Chen Tseng
Chung S Yang
Malcolm C Pike
Memorial Sloan Kettering Cancer Center · USRutgers, The State University of New Jersey · USUniversity of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Mechanistic Studies on Lung Cancer Prevention by Tea PolyphenolsR01CA122474 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI YANG, CHUNG S. · 2008 to 2012
$1.6M
NCI NIH HHS 2P30 CA14089-26NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA122474NCI NIH HHS R01CA122474NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES07048
6 · The paper itself

Abstract

There have been no controlled intervention studies to investigate the effects of green tea on circulating hormone levels, an established breast cancer risk factor. We conducted a double-blind, randomized, placebo-controlled intervention study to investigate the effect of the main green tea catechin, epigallocatechin gallate (EGCG), taken in a green tea extract, polyphenon E (PPE). Postmenopausal women (n = 103) were randomized into three arms: placebo, 400-mg EGCG as PPE, or 800-mg EGCG as PPE as capsules per day for 2 months. Urinary tea catechin and serum estrogen, androgen, lipid, glucose-related markers, adiponectin, and growth factor levels were measured at baseline and at the end of months 1 and 2 of intervention. On the basis of urinary tea catechin concentrations, compliance was excellent. Supplementation with PPE did not produce consistent patterns of changes in estradiol (E2), estrone (E1), or testosterone (T) levels. Low-density lipoprotein (LDL)-cholesterol decreased significantly in both PPE groups but was unchanged in the placebo group; the change in LDL-cholesterol differed between the placebo and PPE groups (P = 0.02). Glucose and insulin levels decreased nonsignificantly in the PPE groups but increased in the placebo group; statistically significant differences in changes in glucose (P = 0.008) and insulin (P = 0.01) were found. In summary, green tea (400- and 800-mg EGCG as PPE; ∼5-10 cups) supplementation for 2 months had suggestive beneficial effects on LDL-cholesterol concentrations and glucose-related markers.

Indexed as

TeaAndrogensCatechinCholesterolDouble-Blind MethodEstrogensFemaleGlucoseHumansLipoproteinsMiddle AgedPostmenopausePrognosisSex Hormone-Binding GlobulinTime FactorsWomen's HealthAndrogensCatechinCholesterolepigallocatechin gallateEstrogensGlucoselipoprotein cholesterolLipoproteinsSex Hormone-Binding GlobulinTea

Identifiers

PMID22246619
PMCPMC3777853
OpenAlexW2135712342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.