Evidence map›Paper›PMID 22246513›Full record

ArticleAIDS and behavior2013

Association between use of specific drugs and antiretroviral adherence: findings from MACH 14.

M I Rosen, A C Black, J H Arnsten, K Goggin, R H Remien, J M Simoni, C E Golin, D R Bangsberg, H Liu

Registry-linked trialOpen access · greenAbstract readComparative Study
In one paragraph

Article in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331978 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

TypeinterventionalSponsorRANDRan2018 to 2021Enrolled306ConditionsHIV/AIDSArmsRise - Treatment Education
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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  13. Childhood Sexual Trauma, Substance Use, and Antiretroviral Therapy Adherence Among Older Adults Living With HIV: A Mediational Analysis.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

M I RosenDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Marc.Rosen@Yale.edu
A C Black
J H Arnsten
K Goggin
R H Remien
J M Simoni
C E Golin
D R Bangsberg
H Liu
Yale University · USAlbert Einstein College of Medicine · USCenter for Global Health · USNew York Psychoanalytic Society and Institute · USUniversity of California, Los Angeles · USUniversity of Missouri–Kansas City · USUniversity of North Carolina Health Care · USUniversity of Washington · US

Funding

WOMEN'S HEALTH AGENDAU01AI038858 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI BENSON, CONSTANCE ANN · 1996 to 2008
$157.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Claude Ann Mellins · 2003 to 2026
$48.2M
Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials UnitUM1AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 2012 to 2026
$44.6M
TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
HIV-1, ETHNICITY, GENDER AND ACUTE STRESS REACTIVITYP01MH049548 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KUMAR, MAHENDRA · 1993 to 2002
$8.5M
Cornell Clinical Trials UnitU01AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GULICK, ROY M. · 2007 to 2011
$6.5M
Improving Adherence to Antiretroviral TherapyR01NR004749 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERLEN, JUDITH A · 1998 to 2007
$3.6M
ART Adherence: Observed Therapy and Enhanced CounselingR01MH068197 · NIMH · UNIVERSITY OF MISSOURI KANSAS CITY · PI GOGGIN, KATHY J · 2004 to 2008
$3.6M
A TRAINING INTERVENTION TO ENHANCE ADHERENCE TO HAARTR01MH061695 · NIMH · RAND CORPORATION · PI KANOUSE, DAVID E · 2000 to 2004
$3.2M
Multi-Site Collaborative Study for Adherence Virologic and Clinical OutcomesR01MH078773 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, HONGHU · 2007 to 2011
$3.1M
Understanding and Improving Adherence in HIV DiseaseR01DA015679 · NIDA · TUFTS MEDICAL CENTER · PI WILSON, IRA B · 2002 to 2005
$3.0M
CDC HHS CC02-SD-003CDC HHS CC99-SD003NIAID NIH HHS AI069419NIAID NIH HHS AI38858NIAID NIH HHS P30 AI050410NIAID NIH HHS R01AI41413NIDA NIH HHS K02DA017277NIDA NIH HHS R01 DA015215NIDA NIH HHS R01DA015679NIDA NIH HHS R01DA11869NIDA NIH HHS R01DA13826NIDA NIH HHS R01DA15215NIMH NIH HHS K23MH01862NIMH NIH HHS P01MH49548NIMH NIH HHS P30 MH043520NIMH NIH HHS R01MH01584NIMH NIH HHS R01 MH054907NIMH NIH HHS R01 MH068197NIMH NIH HHS R01 MH078773NIMH NIH HHS R01MH078773NIMH NIH HHS R01MH54907NIMH NIH HHS R01MH58986NIMH NIH HHS R01 MH61173NIMH NIH HHS R01MH61695NIMH NIH HHS R01MH68197NINR NIH HHS R01NR04749
6 · The paper itself

Abstract

To determine the association between individual substances of abuse and antiretroviral adherence, analyses require a large sample assessed using electronic data monitoring (EDM). In this analysis, EDM data from 1,636 participants in 12 US adherence-focused studies were analyzed to determine the associations between recent use of various substances and adherence during the preceding 4 weeks. In bivariate analyses comparing adherence among patients who had used a specific substance to those who had not, adherence was significantly lower among those who had recently used cocaine, other stimulants or heroin but not among those who had used cannabis or alcohol. In multivariate analyses controlling for sociodemographics, amount of alcohol use and recent use of any alcohol, cocaine, other stimulants and heroin each was significantly negatively associated with adherence. The significant associations of cocaine, other stimulants, heroin, and alcohol use with adherence suggest that these are important substances to target with adherence-focused interventions.

Indexed as

Drug MonitoringAdultAlcohol-Related DisordersAnti-HIV AgentsData CollectionFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedMultivariate AnalysisPrevalenceSocioeconomic FactorsSubstance-Related DisordersUnited StatesAnti-HIV Agents

Identifiers

PMID22246513
PMCPMC3549004
OpenAlexW1963711935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.