ArticleAnnals of biomedical engineering2012
Effect of carrier gas properties on aerosol distribution in a CT-based human airway numerical model.
Article in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Measuring Anatomical Distributions of Ventilation and Aerosol Deposition with PET-CT.Journal of aerosol medicine and pulmonary drug delivery · 2023Review
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- Functional lung imaging in thoracic tumor radiotherapy: Application and progress.Frontiers in oncology · 2022Review
- Differences in Particle Deposition Between Members of Imaging-Based Asthma Clusters.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study.Clinical biomechanics (Bristol, Avon) · 2019Article
- Use of computational fluid dynamics deposition modeling in respiratory drug delivery.Expert opinion on drug delivery · 2019Review
- Ideal Particle Sizes for Inhaled Steroids Targeting Vocal Granulomas: Preliminary Study Using Computational Fluid Dynamics.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2018Article
- A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs.Computational and mathematical methods in medicine · 2018Article
- Numerical simulations of aerosol delivery to the human lung with an idealized laryngeal model, image-based airway model, and automatic meshing algorithm.Computers & fluids · 2017Article
- Automatic construction of subject-specific human airway geometry including trifurcations based on a CT-segmented airway skeleton and surface.Biomechanics and modeling in mechanobiology · 2017Article
- A 4DCT imaging-based breathing lung model with relative hysteresis.Journal of computational physics · 2016Article
- Effect of static vs. dynamic imaging on particle transport in CT-based numerical models of human central airways.Journal of aerosol science · 2016Article
- Fluid flow and particle transport in mechanically ventilated airways. Part I. Fluid flow structures.Medical & biological engineering & computing · 2016Article
- Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung.Journal of aerosol medicine and pulmonary drug delivery · 2016Review
- Efficient methods for implementation of multi-level nonrigid mass-preserving image registration on GPUs and multi-threaded CPUs.Computer methods and programs in biomedicine · 2016Article
- What Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- Assessment of regional ventilation and deformation using 4D-CT imaging for healthy human lungs during tidal breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The effect of carrier gas properties on particle transport in the human lung is investigated numerically in an imaging based airway model. The airway model consists of multi-detector row computed tomography (MDCT)-based upper and intra-thoracic central airways. The large-eddy simulation technique is adopted for simulation of transitional and turbulent flows. The image-registration-derived boundary condition is employed to match regional ventilation of the whole lung. Four different carrier gases of helium (He), a helium-oxygen mixture (He-O(2)), air, and a xenon-oxygen mixture (Xe-O(2)) are considered. A steady inspiratory flow rate of 342 mL/s is imposed at the mouthpiece inlet to mimic aerosol delivery on inspiration, resulting in the Reynolds number at the trachea of Re( t ) ≈ 190, 460, 1300, and 2800 for the respective gases of He, He-O(2), air, and Xe-O(2). Thus, the flow for the He case is laminar, transitional for He-O(2), and turbulent for air and Xe-O(2). The instantaneous and time-averaged flow fields and the laminar/transitional/turbulent characteristics resulting from the four gases are discussed. With increasing Re( t ), the high-speed jet formed at the glottal constriction is more dispersed around the peripheral region of the jet and its length becomes shorter. In the laminar flow the distribution of 2.5-μm particles in the central airways depends on the particle release location at the mouthpiece inlet, whereas in the turbulent flow the particles are well mixed before reaching the first bifurcation and their distribution is strongly correlated with regional ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.