ArticleObesity surgery2012
Comparison of metabolic effects of surgical-induced massive weight loss in patients with long-term remission versus non-remission of type 2 diabetes.
Article in Obesity surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Predictive factors of type 2 diabetes mellitus remission following bariatric surgery: a meta-analysis.Obesity surgery · 2015Pooled it
- Correlation between postoperative weight loss and diabetes mellitus remission: a meta-analysis.Obesity surgery · 2014Pooled it
- Surgical treatment of type 2 diabetes in subjects with mild obesity: mechanisms underlying metabolic improvements.Obesity surgery · 2015Trial
- Attenuated improvements in adiponectin and fat loss characterize type 2 diabetes non-remission status after bariatric surgery.Diabetes, obesity & metabolism · 2014Trial
- Prehabilitation of overweight and obese patients with dysglycemia awaiting bariatric surgery: Predicting the success of obesity treatment.World journal of diabetes · 2022Review
- Bariatric Surgery Resistance: Using Preoperative Lifestyle Medicine and/or Pharmacology for Metabolic Responsiveness.Obesity surgery · 2017Review
- Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity.Obesity science & practice · 2017Article
- Gastric bypass surgery reveals independency of obesity and diabetes melitus type 2.BMC endocrine disorders · 2016Article
- Long-Term Outcomes of Biliopancreatic Diversion on Glycemic Control, Insulin Sensitivity and Beta Cell Function.Obesity surgery · 2016Article
- Adipokine Pattern After Bariatric Surgery: Beyond the Weight Loss.Obesity surgery · 2016Review
- Serum Leptin and Adiponectin Concentration in Type 2 Diabetes Patients in the Short and Long Term Following Biliopancreatic Diversion.Obesity surgery · 2016Article
- Treatment of Obesity: Weight Loss and Bariatric Surgery.Circulation research · 2016Review
- Influence of Insulin Resistance Status on the Development of Gallstones Following Roux-En-Y Gastric Bypass: a Prospective Cohort Study.Obesity surgery · 2016Observational
- Obesity-related immune responses and their impact on surgical outcomes.International journal of obesity (2005) · 2015Review
- Article
- Correlation between post over preoperative surrogate insulin resistance indexes' ratios and reversal of metabolic syndrome after Roux-en-Y gastric bypass.Obesity surgery · 2014Article
- Insulin-like growth factor 1 predicts post-load hypoglycemia following bariatric surgery: a prospective cohort study.PloS one · 2014Article
- Immune cell-mediated inflammation and the early improvements in glucose metabolism after gastric banding surgery.Diabetologia · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the pathophysiological mechanisms underlying the non-remission of type 2 diabetes in Roux-en-Y gastric bypass (RYGB) patients.
methodsA group of patients not in remission (NR) was formed (n = 13). A remission group (R) was composed of patients who had undergone normalization of fasting glycemia and A1c, without anti-diabetic drugs and matched for selected baseline characteristics (i.e., duration of disease, previous BMI, final BMI, fat distribution, and age; n = 15). A control group of lean subjects (n = 41) was formed.
resultsThe NR group had higher uric acid (5.1 vs. 3.9 mg/dL), number of leukocytes (6,866.9 vs. 5,423.6), hs-CRP (0.27 vs. 0.12 mg/dL), MCP-1 (118.4 vs. 64.4 ng/mL), HOMA-IR, and AUC(glucose) but lower adiponectin (9.4 vs. 15.4 ng/mL), leptin (12.7 vs. 20.7 ng/mL), and AUC(GLP-1) in comparison to R group; the NR group also had lower leptin and higher adiponectin, HOMA-IR, AUC(glucose), AUC(C-peptide), AUC(glucagon), and AUC(GLP-1) than controls. The R group had lower MCP-1 and higher adiponectin compared to controls. Insulin sensitivity was significantly lower in the NR group than in the R and control groups. The insulin secretion index values were lower in the NR group than in the R and control groups.
conclusionsThis study found greater insulin resistance, lower insulin secretion, persistent adiposopathy and chronic subclinical inflammation, and less robust incretin response in the NR group despite a similar level of weight loss. Persistently altered pathophysiological mechanisms can be related to the lack of remission of type 2 diabetes after RYGB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.