ArticleOptometry and vision science : official publication of the American Academy of Optometry2012
Assessment of axial length measurements in mouse eyes.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Model of naturally occurring refractive error (NORE) in mice.bioRxiv : the preprint server for biology · 2026Article
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- Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice.European journal of medical research · 2025Article
- Development of a novel SupraChoroidal-to-Optic-NervE (SCONE) drug delivery system.Drug delivery · 2024Article
- Comparison of Eye Axial Length Measurements Taken Using Partial Coherence Interferometry and OCT Biometry.Vision (Basel, Switzerland) · 2024Article
- Modeling complex age-related eye disease.Progress in retinal and eye research · 2024Review
- Longitudinal study of microphthalmia in connexin 50 knockout mice using spectral-domain optical coherence tomography.Frontiers in ophthalmology · 2024Article
- Multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence imaging of USH2A knockout rabbits.Scientific reports · 2023Article
- The Bovine Ex Vivo Retina: A Versatile Model for Retinal Neuroscience.Investigative ophthalmology & visual science · 2023Article
- Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits.Scientific reports · 2023Article
- Mice LackingInternational journal of molecular sciences · 2022Article
- Melanopsin modulates refractive development and myopia.Experimental eye research · 2022Article
- Article
- Normative Data of Axial Length, Retinal Thickness Measurements, Visual Evoked Potentials, and Full-Field Electroretinography in Female, Wild-Type Minipigs.Translational vision science & technology · 2021Article
- The effect of Wnt/β-catenin pathway on the scleral remolding in the mouse during form deprivation.International ophthalmology · 2021Article
- A smartphone based method for mouse fundus imaging.Experimental eye research · 2021Review
- Gelling hypotonic polymer solution for extended topical drug delivery to the eye.Nature biomedical engineering · 2020Article
- Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure.Disease models & mechanisms · 2020Article
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7 authors.
Funding
Abstract
purposeTo compare measurements of murine ocular axial lengths (ALs) made with 780 nm partial coherence interferometry (PCI) and 1310 nm spectral domain-optical coherence tomography (SD-OCT).
methodsAL was measured at postnatal day (P) 58 in C57BL/6J mice. Repeated AL measurements were taken using a custom-made 780 nm PCI and a commercial 1310 nm SD-OCT. Intra- and interuser variability was assessed along the central optical axis and 2-degree off-axes angles with the SD-OCT. Data were collected and analyzed using Cronbach alpha (α), Bland-Altman coefficient of repeatability, agreement plots, and intraclass correlation coefficients (ICC).
resultsAL measurements agreed well between the two instruments (3.262 ± 0.042 mm for PCI; 3.264 ± 0.047 mm for SD-OCT; n = 20 eyes). The ICC for PCI compared with SD-OCT was 0.92, confirming high agreement between the two instruments. Intrauser ICC for the PCI and SD-OCT were 0.814 and 0.995, respectively. Similarly, interuser ICC for PCI and SD-OCT were 0.970 and 0.943, respectively. Using SD-OCT, a 2-degree misalignment of the eye along the horizontal meridian produced mean differences in AL of -0.002 ± 0.017 mm relative to the centrally aligned images, whereas similar misalignment along the vertical meridian created 0.005 ± 0.018 mm differences in AL measurements.
conclusionsAL measurements from the 780 nm PCI and 1310 nm SD-OCT correlate well. Multiple statistical indices indicate that both instruments have good precision and agreement for measuring murine ocular AL in vivo. Although the vertical meridian had the greater variability in AL in the small mouse eye; 2-degree off-axes differences were within the SD of centrally aligned AL.
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