ArticleAmerican journal of respiratory and critical care medicine2012
The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Gene Expression Analysis to Assess the Relevance of Rodent Models to Human Lung Injury.American journal of respiratory cell and molecular biology · 2017Pooled it
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- Investigation of lactotransferrin messenger RNA expression levels as an anti-type 2 asthma biomarker.The Journal of allergy and clinical immunology · 2024Article
- Transcriptomic analysis identified SLC40A1 as a key iron metabolism-related gene in airway macrophages in childhood allergic asthma.Frontiers in cell and developmental biology · 2023Article
- The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing.Signal transduction and targeted therapy · 2022Article
- Analysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus.BMC pulmonary medicine · 2022Article
- Nasal DNA methylation differentiates severe from non-severe asthma in African-American children.Allergy · 2021Article
- Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.JCI insight · 2020Article
- Epigenome-wide association study of asthma and wheeze characterizes loci withinAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Article
- An epigenome-wide association study of total serum IgE in Hispanic children.The Journal of allergy and clinical immunology · 2017Article
- The environment, epigenome, and asthma.The Journal of allergy and clinical immunology · 2017Review
- The nasal methylome and childhood atopic asthma.The Journal of allergy and clinical immunology · 2017Article
- Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation.Nature · 2016Article
- Lynx: a knowledge base and an analytical workbench for integrative medicine.Nucleic acids research · 2016Article
- Epigenome variation in severe asthma.Biological research for nursing · 2015Article
- Integrative genetic analysis of allergic inflammation in the murine lung.American journal of respiratory cell and molecular biology · 2014Article
- Ex vivo chemical cytometric analysis of protein tyrosine phosphatase activity in single human airway epithelial cells.Analytical chemistry · 2014Article
- Measurement of protein tyrosine phosphatase activity in single cells by capillary electrophoresis.Analytical chemistry · 2013Article
- Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.Journal of proteome research · 2013Article
- The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleGene expression profiling of airway epithelial and inflammatory cells can be used to identify genes involved in environmental asthma.
methodsAirway epithelia and inflammatory cells were obtained via bronchial brush and bronchoalveolar lavage (BAL) from 39 subjects comprising three phenotypic groups (nonatopic nonasthmatic, atopic nonasthmatic, and atopic asthmatic) 4 hours after instillation of LPS, house dust mite antigen, and saline in three distinct subsegmental bronchi. RNA transcript levels were assessed using whole genome microarrays. MEASUREMENTS AND MAIN
resultsBaseline (saline exposure) differences in gene expression were related to airflow obstruction in epithelial cells (C3, ALOX5AP, CCL18, and others), and to serum IgE (innate immune genes and focal adhesion pathway) and allergic-asthmatic phenotype (complement genes, histone deacetylases, and GATA1 transcription factor) in inflammatory cells. LPS stimulation resulted in pronounced transcriptional response across all subjects in both airway epithelia and BAL cells, with strong association to nuclear factor-κB and IFN-inducible genes as well as signatures of other transcription factors (NRF2, C/EBP, and E2F1) and histone proteins. No distinct transcriptional profile to LPS was observed in the asthma and atopy phenotype. Finally, although no consistent expression changes were observed across all subjects in response to house dust mite antigen stimulation, we observed subtle differences in gene expression (e.g., GATA1 and GATA2) in BAL cells related to the asthma and atopy phenotype.
conclusionsOur results indicate that among individuals with allergic asthma, transcriptional changes in airway epithelia and inflammatory cells are influenced by phenotype as well as environmental exposures.
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