ArticleClinical oral investigations2012
Characterization of Aggregatibacter actinomycetemcomitans strains in periodontitis patients in Germany.
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence of the JP2 genotype of Aggregatibacter actinomycetemcomitans in the world population: a systematic review.Clinical oral investigations · 2022Pooled it
- Article
- Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.Advances in experimental medicine and biology · 2022Article
- Etiology of aggressive periodontitis in individuals of African descent.The Japanese dental science review · 2021Review
- JP2 Genotype ofPathogens (Basel, Switzerland) · 2020Article
- Accuracy of commercial kits and published primer pairs for the detection of periodontopathogens.Clinical oral investigations · 2016Article
- Oral and endotracheal tubes colonization by periodontal bacteria: a case-control ICU study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Article
- Increased periodontal inflammation in women with preterm premature rupture of membranes.Clinical oral investigations · 2015Article
- Subgingival plaque sampling after combined mechanical and antibiotic nonsurgical periodontal therapy.Clinical oral investigations · 2015Article
- Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis.Journal of oral microbiology · 2014Review
- Leukotoxic activity of Aggregatibacter actinomycetemcomitans and periodontal attachment loss.PloS one · 2014Article
- Oral microbiota in Swiss adolescents.Clinical oral investigations · 2013Article
- Article
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAggregatibacter actinomycetemcomitans strains of serotype b and with a deletion of 530 bp in the promoter region of the leukotoxin gene (JP2 clone) are known to be associated with severe periodontitis. Our study was aimed to detect virulence genes of A. actinomycetemcomitans strains obtained from patients living in four German cities with different proportions of immigrants. MATERIAL AND
methodsSamples were obtained from severe periodontitis patients in Frankfurt, Hamburg, Leipzig, and Jena. Those being tested positive for A. actinomycetemcomitans were analyzed for serotypes, deletion in the promoter region of the leukotoxin gene, presence of cytolethal distending toxin encoding genes (cdtA, cdtB, and cdtC) and fibril gene1(flp-1).
resultsFrom all 99 A. actinomycetemcomitans-positive samples, the JP2 clone was found in two immigrants in Frankfurt. Seventy strains were tested positive for the cdtA, 52 for cdtB, and 92 for cdtC and flp-1 genes. Twenty-five strains belonged to serotype a, 22 to serotype b, 21 to serotype c, 31 to the others or could not be serotyped, respectively. The distribution of the serotypes differed between the cities. Further, differences regarding the serotypes were also significant between natives and immigrants.
conclusionsThe JP2 clone is not spread within the Caucasian inhabitants in German cities. The serotypes distribution seems to be influenced by the numbers of immigrants in the cities. CLINICAL RELEVANCE: Patients originated from North Africa should be especially screened for the presence of the deletion in the ltx promoter region.
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