Evidence map›Paper›PMID 22246042›Full record

ReviewCurrent opinion in supportive and palliative care2012

Visceral pain: the ins and outs, the ups and downs.

Shafaq Sikandar, Anthony H Dickenson

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Current opinion in supportive and palliative care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07246785 phase4terminatednot on this mapstarted 2025, after this paper: background citation

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled13ConditionsLaparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous AnalgesiaArmsHigh-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon, Morphine
NCT07525986 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Tria

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled140ConditionsLaparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous AnalgesiaArmsHigh-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon, Morphine
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 238 citations in OpenAlex.

  1. Pooled it
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  7. Progress in pain mechanisms and management.Signal transduction and targeted therapy · 2026
    Review
  8. Article
  9. Cancer pain.Nature reviews. Disease primers · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
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  15. Mechanism, Dose, and Administration of Dexmedetomidine in Managing Visceral Pain Associated With Surgery: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shafaq SikandarDepartment of Neuroscience, Physiology and Pharmacology University College London, London UK. shafaq.sikandar@ucl.ac.uk
Anthony H Dickenson
University College London · GB

Funding

British Heart Foundation 19444Wellcome Trust 083259
6 · The paper itself

Abstract

purpose of reviewVisceral pain represents a major clinical problem, yet far less is known about its mechanisms compared with somatic pains, for example, from cutaneous and muscular structures. RECENT

findingsIn this review, we describe the neuroanatomical bases of visceral pain signalling in the peripheral and central nervous system, comparing to somatic pains and also the channels and receptors involved in these events. We include an overview of potential new targets in the context of mechanisms of visceral pain and hypersensitivity. SUMMARY: This review should inform on the recognition of what occurs in patients with visceral pain, why comorbidities are common and how analgesic treatments work.

Indexed as

Central Nervous SystemHumansHyperalgesiaNociceptionNociceptive PainPain MeasurementPeripheral Nervous System DiseasesVisceral AfferentsVisceral Pain

Identifiers

PMID22246042
PMCPMC3272481
OpenAlexW2149571484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.