ReviewSeminars in cell & developmental biology2012
A new branch on the tree: next-generation sequencing in the study of cancer evolution.
Review in Seminars in cell & developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Transcriptomic profiling on localized gastric cancer identified CPLX1 as a gene promoting malignant phenotype of gastric cancer and a predictor of recurrence after surgery and subsequent chemotherapy.Journal of gastroenterology · 2022Article
- G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer.British journal of cancer · 2021Article
- Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.EBioMedicine · 2017Review
- PhyloOncology: Understanding cancer through phylogenetic analysis.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Pancreatic cancer biology and genetics from an evolutionary perspective.Nature reviews. Cancer · 2016Review
- Targeting metastasis.Nature reviews. Cancer · 2016Review
- Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection.Molecular medicine reports · 2015Article
- Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- A phylogenetic model for understanding the effect of gene duplication on cancer progression.Nucleic acids research · 2014Article
- Inferring clonal evolution of tumors from single nucleotide somatic mutations.BMC bioinformatics · 2014Article
- Article
- How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Next generation sequencing in cancer research and clinical application.Biological procedures online · 2013Article
- Impact of tumor progression on cancer incidence curves.Cancer research · 2013Article
- DNA qualification workflow for next generation sequencing of histopathological samples.PloS one · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cancer is a disease caused by the accumulation of genetic alterations in association with successive waves of clonal expansion. Mapping of the human genome sequence, in conjunction with technical advances in the ability to sequence entire genomes, have provided new insight into the mutational spectra and genetic events associated with clonal evolution of cancer. Moving forward, a clearer understanding of those alterations that undergo positive and negative selection throughout carcinogenesis and leading to metastatic dissemination would provide a boon not only to our understanding of cancer evolution, but to the development of potential targets for therapeutic intervention as well.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.