ArticleBiomaterials2012
Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Transplacental Toxicity of Zinc Oxide Nanoparticles: Maternal-Fetal DNA Damage and Organ Accumulation.Nanomaterials (Basel, Switzerland) · 2026Article
- Transforming the Buckyball: Regioselective Synthesis of Water-Soluble [60]Fullerene Derivatives for Biomedical Applications.Molecules (Basel, Switzerland) · 2026Review
- Water-soluble fullerene derivatives mitigate cranial radiation-induced neuroinflammation and cognitive dysfunction.Biomedical microdevices · 2026Article
- Research Progress on Nucleus-Targeting Carbon Nanoparticles for Tumor Imaging and Therapy.International journal of nanomedicine · 2025Review
- Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose.Environmental analysis, health and toxicology · 2023Article
- Review
- Sensing and Stimulation Applications of Carbon Nanomaterials in Implantable Brain-Computer Interface.International journal of molecular sciences · 2023Review
- Article
- CNanoscale · 2022Article
- DFT study on the adsorption of 5-fluorouracil on BRSC advances · 2021Article
- Interactions of a Water-Soluble Glycofullerene with Glucose Transporter 1. Analysis of the Cellular Effects on a Pancreatic Tumor Model.Nanomaterials (Basel, Switzerland) · 2021Article
- DFT calculations towards the geometry optimization, electronic structure, infrared spectroscopy and UV-vis analyses of Favipiravir adsorption on the first-row transition metals doped fullerenes; a new strategy for COVID-19 therapy.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2021Article
- Glycofullerenes as non-receptor tyrosine kinase inhibitors- towards better nanotherapeutics for pancreatic cancer treatment.Scientific reports · 2020Article
- Evaluation of the Biodistribution of Serinolamide-Derivatized CNanomaterials (Basel, Switzerland) · 2020Article
- Mechano-signalling, induced by fullerene CInternational journal of nanomedicine · 2019Article
- Development of photoactive Sweet-CNanomedicine (London, England) · 2018Article
- Fullerenemalonates inhibit amyloid beta aggregation,RSC advances · 2018Article
- CNanoscale research letters · 2018Article
- The effects of non-invasive radiofrequency electric field hyperthermia on biotransport and biodistribution of fluorescent [60]fullerene derivative in a murine orthotopic model of breast adenocarcinoma.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- The influence of cell and nanoparticle properties on heating and cell death in a radiofrequency field.Acta biomaterialia · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A highly water-soluble, non-ionic, and non-cytotoxic fullerene malonodiserinolamide-derivatized fullerene C(60) (C(60)-ser) is under investigation as a potential nanovector to deliver biologic and cancer drugs across biological barriers. Using laser-scanning confocal microscopy and flow cytometry, we find that PF-633 fluorophore conjugated C(60)-ser nanoparticles (C(60)-serPF) are internalized within living cancer cells in association with serum proteins through multiple energy-dependent pathways, and escape endocytotic vesicles to eventually localize and accumulate in the nucleus of the cells through the nuclear pore complex. Furthermore, in a mouse model of liver cancer, the C(60)-serPF conjugate is detected in most tissues, permeating through the altered vasculature of the tumor and the tightly-regulated blood brain barrier while evading the reticulo-endothelial system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.