Trial reportAmerican journal of ophthalmology2012
Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up.
Trial report in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 471 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Primary Open Angle Glaucoma: a Three-year Comparative Study
The AGS Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study
Who cites it
471 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,090 citations in OpenAlex.
- Efficacy and safety of goniotomy and gonioscopy-assisted transluminal trabeculotomy for exfoliation glaucoma: a systematic review and single-arm meta-analysis.Frontiers in medicine · 2026Pooled it
- Efficacy of anti-vascular endothelial growth factor and mitomycin C on wound healing after trabeculectomy in glaucoma patients: A meta-analysis.International wound journal · 2024Pooled it
- Comparison of tube shunt implantation and trabeculectomy for glaucoma: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- The Outcomes of XEN Gel Stent Implantation: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.JAMA ophthalmology · 2025Trial
- Outcomes of Susanna UF implants in refractory congenital glaucoma.Clinics (Sao Paulo, Brazil) · 2025Trial
- Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.Ophthalmology · 2024Trial
- Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up.Ophthalmology · 2022Trial
- Risk Factors for Failure of Tube Shunt Surgery: A Pooled Data Analysis.American journal of ophthalmology · 2022Trial
- Twelve-month results of ab interno trabeculectomy with Kahook Dual Blade: an interventional, randomized, controlled clinical study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Trial
- Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS).BMJ (Clinical research ed.) · 2021Trial
- Clinical Outcomes of Trabecular Micro-Bypass Stent in Patients with Moderate-to-Severe Open-Angle Glaucoma.Korean journal of ophthalmology : KJO · 2026Article
- Patterns of Glaucoma Treatment Use in Asian American Patients With Primary Open-Angle Glaucoma.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- Factors Associated with Favorable One-Year Outcomes After PreserFlo MicroShunt Implantation: Insights from Anterior Segment Optical Coherence Tomography.Advances in therapy · 2026Article
- Endophthalmitis following glaucoma drainage device surgery.Eye (London, England) · 2026Article
- Risk-Stratified Interventional Management and Surgical Decision-Making in Primary Glaucoma.Biomedicines · 2026Review
- Risk factors for tube exposure following Baerveldt glaucoma implantation and overlying tissue thickness assessed by anterior segment optical coherence tomography.Japanese journal of ophthalmology · 2026Article
- Evaluation of tube extender use in glaucoma management: insights from a cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Initial aqueous suppressant therapy after glaucoma drainage device implantation: a systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Fibrous ingrowth: an overlooked cause of Ahmed Glaucoma Valve failure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
411 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo report 5-year treatment outcomes in the Tube Versus Trabeculectomy (TVT) Study.
designMulticenter randomized clinical trial.
methodsSETTINGS: Seventeen clinical centers. STUDY POPULATION: Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and uncontrolled glaucoma with intraocular pressure (IOP) ≥18 mm Hg and ≤40 mm Hg on maximum tolerated medical therapy.
interventionsTube shunt (350-mm(2) Baerveldt glaucoma implant) or trabeculectomy with mitomycin C ([MMC]; 0.4 mg/mL for 4 minutes).
main outcome measuresIOP, visual acuity, use of supplemental medical therapy, and failure (IOP >21 mm Hg or not reduced by 20%, IOP ≤5 mm Hg, reoperation for glaucoma, or loss of light perception vision).
resultsA total of 212 eyes of 212 patients were enrolled, including 107 in the tube group and 105 in the trabeculectomy group. At 5 years, IOP (mean ± SD) was 14.4 ± 6.9 mm Hg in the tube group and 12.6 ± 5.9 mm Hg in the trabeculectomy group (P = .12). The number of glaucoma medications (mean ± SD) was 1.4 ± 1.3 in the tube group and 1.2 ± 1.5 in the trabeculectomy group (P = .23). The cumulative probability of failure during 5 years of follow-up was 29.8% in the tube group and 46.9% in the trabeculectomy group (P = .002; hazard ratio = 2.15; 95% confidence interval = 1.30 to 3.56). The rate of reoperation for glaucoma was 9% in the tube group and 29% in the trabeculectomy group (P = .025).
conclusionsTube shunt surgery had a higher success rate compared to trabeculectomy with MMC during 5 years of follow-up in the TVT Study. Both procedures were associated with similar IOP reduction and use of supplemental medical therapy at 5 years. Additional glaucoma surgery was needed more frequently after trabeculectomy with MMC than tube shunt placement.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.