Evidence map›Paper›PMID 22245389›Full record

ReviewJournal of immunological methods2012

Cellular immune response parameters that influence IgE sensitization.

Pamela A Frischmeyer-Guerrerio, John T Schroeder

Abstract readReview
In one paragraph

Review in Journal of immunological methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Isolation of Human Basophils.Current protocols in immunology · 2016
    Article
  3. Article
  4. Basophils and skin disorders.The Journal of investigative dermatology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Pamela A Frischmeyer-GuerrerioThe Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins Children's Hospital, Johns Hopkins University, USA.
John T Schroeder
Johns Hopkins All Children's Hospital · USJohns Hopkins Bayview Medical Center · US

Funding

Interrelation between FcERI Expression, Cellular Sensitivity, In vivo ResponsesU19AI070345 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MACGLASHAN, DONALD W · 2006 to 2010
$6.5M
Investigation of the Role of TGF Beta in TH2-Mediated DiseaseK23AI091869 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GUERRERIO, PAMELA ANN · 2011 to 2014
$537k
Immune Cell Responses in Food HypersensitivityR21AI079853 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SCHROEDER, JOHN T. · 2008 to 2009
$451k
Plasma Serum Based Biomarkers in Sublingual Oral Immunotherapy for Milk AllergyR21AI092443 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SCHROEDER, JOHN T. · 2012 to 2013
$446k
Basophils in Modulating Th2 Responses in Human Allergic DiseaseR56AI091631 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SCHROEDER, JOHN T. · 2011 to 2011
$410k
NIAID NIH HHS K23 AI091869NIAID NIH HHS R21 AI079853NIAID NIH HHS R21AI079853NIAID NIH HHS R21 AI092443NIAID NIH HHS R56 AI091631NIAID NIH HHS U19 AI070345NIAID NIH HHS U19 AI070345-PROJECT 3
6 · The paper itself

Abstract

In vitro basophil responses have long been used in mechanistic studies to help assess the human allergic diathesis, particularly during therapeutic intervention. Recent evidence points to the use of dendritic cells (DCs) in also being valuable in evaluating therapies aimed at lessening disease through immunomodulation. This review article therefore takes a look at some of the recent advances in old and new assays employing both basophils and DCs, with the added perception that the responses mediated by two cell types are insightful towards understanding immune cell mechanisms underlying allergic disease.

Indexed as

Immunity, CellularImmunologic TestsAllergensAnimalsBasophilsBiomarkersDendritic CellsHumansHypersensitivityImmunoglobulin EInflammation MediatorsPredictive Value of TestsPrognosisAllergensBiomarkersImmunoglobulin EInflammation Mediators

Identifiers

PMID22245389
PMCPMC4024666
OpenAlexW2098043762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.