ArticleBrain research1990
Cellular localization of proenkephalin mRNA and enkephalin peptide products in cultured astrocytes.
Article in Brain research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 90 citations in OpenAlex.
- Peripherally Acting Opioids in Orofacial Pain.Frontiers in neuroscience · 2021Review
- Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain.Cell transplantation · 2018Article
- Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.Frontiers in pediatrics · 2017Review
- Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus.Iranian journal of basic medical sciences · 2014Article
- Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes.ACS chemical neuroscience · 2014Article
- Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors.International review of neurobiology · 2014Review
- Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Opiate drug use and the pathophysiology of neuroAIDS.Current HIV research · 2012Review
- Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study.Anatomy & cell biology · 2012Article
- Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.Journal of neurochemistry · 2009Article
- The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation.Molecular biology of the cell · 2009Article
- Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability.Cerebellum (London, England) · 2003Review
- Article
- kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.Brain research · 1996Article
- mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism.Brain research · 1996Article
- Localization of vasopressin mRNA and immunoreactivity in pituicytes of pituitary stalk-transected rats after osmotic stimulation.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The transcriptional regulation of the preproenkephalin gene.The Biochemical journal · 1995Review
- Morphine inhibits Purkinje cell survival and dendritic differentiation in organotypic cultures of the mouse cerebellum.Experimental neurology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To identify the possible cellular sites of opioid gene expression during ontogeny, proenkephalin mRNA and enkephalin peptide expression were examined, respectively, by in situ hybridization and immunocytochemistry in organotypic explants of rat cerebellum and in astrocyte-enriched cultures of murine cerebral hemispheres. High levels of proenkephalin mRNA and enkephalin immunoreactivity were detected in immature cells identified as astrocytes. Double-labeling studies combining in situ hybridization and immunocytochemical localization of the astrocytic marker, glial fibrillary acidic protein, provided direct evidence that proenkephalin mRNA is expressed by astrocytes in culture. Based on previous studies that Met-enkephalin can inhibit astrocyte growth in vitro, the present results suggest that proenkephalin gene expression by astrocytes is important during central nervous system maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.