ArticleNeurotoxicology2012
Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies.
Article in Neurotoxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Sensitive development windows of prenatal air pollution and cognitive functioning in preschool age Mexican children.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Article
- Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer's Clinical Notes.Geriatrics (Basel, Switzerland) · 2021Article
- Potential health effects of emerging environmental contaminants perfluoroalkyl compounds.Yeungnam University journal of medicine · 2018Review
- In search of a comprehensible set of endpoints for the routine monitoring of neurotoxicity in vertebrates: sensory perception and nerve transmission in zebrafish (Danio rerio) embryos.Environmental science and pollution research international · 2018Article
- The interaction of genetics and environmental toxicants in amyotrophic lateral sclerosis: results from animal models.Neural regeneration research · 2017Review
- Programmed Effects in Neurobehavior and Antioxidative Physiology in Zebrafish Embryonically Exposed to Cadmium: Observations and Hypothesized Adverse Outcome Pathway Framework.International journal of molecular sciences · 2016Article
- Managing mercury exposure in northern Canadian communities.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Review
- Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Concentrations of persistent organic pollutants in maternal and cord blood from the maternal-infant research on environmental chemicals (MIREC) cohort study.Environmental health : a global access science source · 2016Article
- Environmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the Room.International journal of environmental research and public health · 2016Review
- Developmental Deltamethrin Exposure Causes Persistent Changes in Dopaminergic Gene Expression, Neurochemistry, and Locomotor Activity in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Hippocampal developmental vulnerability to methylmercury extends into prepubescence.Frontiers in neuroscience · 2015Article
- Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties.International journal of hygiene and environmental health · 2015Article
- Effects of early life exposure to methylmercury in Daphnia pulex on standard and reduced food ration.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Gene expression in teratogenic exposures: a new approach to understanding individual risk.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury.Neurochemistry international · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
To date, only a small number of commercial chemicals have been tested and documented as developmental neurotoxicants. Moreover, an increasing number of epidemiological, clinical and experimental studies suggest an association between toxicant or drug exposure during the perinatal period and the development of metabolic-related diseases and neurotoxicity later in life. The four speakers at this symposium presented their research results on different neurotoxic chemicals relating to the developmental origins of health and adult disease (DOHaD). Philippe Grandjean presented epidemiological data on children exposed to inorganic mercury and methylmercury, and discussed the behavioral outcome measures as they relate to age and stage of brain development. Donald A. Fox presented data that low-dose human equivalent gestational lead exposure produces late-onset obesity only in male mice that is associated with neurodegeneration. Didima de Groot presented results on prenatal exposure of rats to methylazoxymethanol and discussed the results in light of the etiology of western Pacific amyotrophic lateral sclerosis and Parkinson-dementia complex. Merle G. Paule addressed the long-term changes in learning, motivation and short-term memory in aged Rhesus monkeys following acute 24 h exposure to ketamine during early development. Overall, these presentations addressed fundamental issues in the emerging areas of lifetime neurotoxicity testing, differential vulnerable periods of exposure, nonmonotonic dose-response effects and neurotoxic risk assessment. The results indicate that developmental neurotoxicity results in permanent changes, thus emphasizing the need to prevent such toxicity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.