ArticleStructure (London, England : 1993)2012
Structural basis for molecular interactions involving MRG domains: implications in chromatin biology.
Article in Structure (London, England : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- MORF4L1 regulation and its role in chromatin remodeling, DNA damage, cellular senescence, and cardiometabolic disease.Vascular pharmacology · 2026Review
- Structural and functional insights into the epigenetic regulator MRG15.Acta pharmacologica Sinica · 2024Review
- SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.Development (Cambridge, England) · 2023Article
- Article
- Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.Development (Cambridge, England) · 2018Article
- PALB2 (partner and localizer of BRCA2).Atlas of genetics and cytogenetics in oncology and haematology · 2018Article
- Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.Nature communications · 2017Article
- The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence.Molecular and cellular biology · 2017Article
- MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.Molecular cancer research : MCR · 2017Article
- Structural Basis for Multi-specificity of MRG Domains.Structure (London, England : 1993) · 2015Article
- Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2.G3 (Bethesda, Md.) · 2015Article
- Nucleosome contact triggers conformational changes of Rpd3S driving high-affinity H3K36me nucleosome engagement.Cell reports · 2015Article
- PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.Biochimica et biophysica acta · 2014Review
- Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics.Molecular & cellular proteomics : MCP · 2013Article
- Article
- Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex.Journal of molecular biology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
MRG15 is a member of the mortality family of transcription factors that targets a wide variety of multiprotein complexes involved in transcription regulation, DNA repair, and alternative splicing to chromatin. The structure of the apo-MRG15 MRG domain implicated in interactions with diverse proteins has been described, but not in complex with any of its targets. Here, we structurally and functionally characterize the interaction between MRG15 and Pf1, two constitutively associated subunits of the histone deacetylase-associated Rpd3S/Sin3S corepressor complex. The MRG domain adopts a structure reminiscent of the apo state, whereas the Pf1 MRG-binding domain engages two discrete hydrophobic surfaces on the MRG domain via a bipartite motif comprising an α-helix and a segment in an extended conformation, both of which are critical for high-affinity interactions. Multiple MRG15 interactors share an FxLP motif in the extended segment, but equivalent sequence/helical motifs are not readily evident, implying potential diversity in MRG-recognition mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.