ReviewJournal of shoulder and elbow surgery2012
Biomimetic scaffold design for functional and integrative tendon repair.
Review in Journal of shoulder and elbow surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Multilayered electrospun scaffolds for tendon tissue engineering.Tissue engineering. Part A · 2013Trial
- Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration.Science advances · 2026Article
- Optimizing strategies in tendon tissue engineering through effective scaffold design: overview of recent advancements.Regenerative medicine · 2026Review
- Photosensitive and extracellular matrix-mimicking hydrogels promote the tendon-bone healing in rotator cuff injury.Journal of materials science. Materials in medicine · 2026Article
- Rotator cuff repair and biologic augmentation-what do we know?JSES reviews, reports, and techniques · 2026Review
- Review
- Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair.Bioactive materials · 2025Article
- Engineering a Biomimetic Multiphasic Suture Anchor System for Enhanced Rotator Cuff Enthesis Regeneration.bioRxiv : the preprint server for biology · 2025Article
- Superior Capsule Reconstruction Graft Selection: The Influence of Biological Properties of Grafts on Healing and Re-Tearing.Bioengineering (Basel, Switzerland) · 2025Review
- Recent advances in gradient biomimetic scaffolds for tendon-bone interface regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- ZIF-8-loaded decellularized porcine annulus fibrosus bioadhesive enhances rotator cuff tendon-to-bone healing in a rat model.Frontiers in bioengineering and biotechnology · 2025Article
- Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair.Biomaterials science · 2024Article
- Scaffold-based tissue engineering strategies for soft-hard interface regeneration.Regenerative biomaterials · 2023Review
- Optimizing Tenogenic Differentiation of Equine Adipose-Derived Mesenchymal Stem Cells (eq-ASC) Using TGFB3 Along with BMP Antagonists.Cell journal · 2022Article
- Rotator cuff repair using a bioresorbable nanofiber interposition scaffold: a biomechanical and histologic analysis in sheep.Journal of shoulder and elbow surgery · 2022Article
- Biomimetic strategies for tendon/ligament-to-bone interface regeneration.Bioactive materials · 2021Review
- Augmenting Tendon-to-Bone Repair with Functionally Graded Scaffolds.Advanced healthcare materials · 2021Review
- Bioactive Polymeric Materials for the Advancement of Regenerative Medicine.Journal of functional biomaterials · 2021Review
- Tissue Engineering for the Insertions of Tendons and Ligaments: An Overview of Electrospun Biomaterials and Structures.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Rotator cuff tears represent the most common shoulder injuries in the United States. The debilitating effect of this degenerative condition coupled with the high incidence of failure associated with existing graft choices underscores the clinical need for alternative grafting solutions. The 2 critical design criteria for the ideal tendon graft would require the graft to not only exhibit physiologically relevant mechanical properties but also be able to facilitate functional graft integration by promoting the regeneration of the native tendon-to-bone interface. Centered on these design goals, this review will highlight current approaches to functional and integrative tendon repair. In particular, the application of biomimetic design principles through the use of nanofiber- and nanocomposite-based scaffolds for tendon tissue engineering will be discussed. This review will begin with nanofiber-based approaches to functional tendon repair, followed by a section highlighting the exciting research on tendon-to-bone interface regeneration, with an emphasis on implementation of strategic biomimicry in nanofiber scaffold design and the concomitant formation of graded multi-tissue systems for integrative soft-tissue repair. This review will conclude with a summary and discussion of future directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.