ArticleDrug and alcohol dependence2012
Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms.
Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Trial
- The BioSUD Biobank as a genomic resource for substance use disorders in Italy.Scientific reports · 2025Article
- "General Addiction Liability" Revisited.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Atypical effective connectivity from the frontal cortex to striatum in alcohol use disorder.Translational psychiatry · 2024Article
- Generalized genetic liability to substance use disorders.The Journal of clinical investigation · 2024Review
- Discrimination and Tobacco Use Outcomes Among US Adults: Effect Modification by Race/Ethnicity.Journal of racial and ethnic health disparities · 2024Article
- Distress about social problems and tobacco and cannabis use outcomes among young adults in Los Angeles County.Preventive medicine · 2024Article
- Genetic and shared environmental factors explain the association between adolescent polysubstance use and high school noncompletion.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Article
- Individual Differences in Substance Use Motives, Trauma, and Stress Among College-Based Polysubstance Users.Substance use & misuse · 2024Article
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2023Article
- Multi-Polygenic Analysis of Nicotine Dependence in Individuals of European Ancestry.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Traditional risk and cultural protection: Correlates of alcohol and cannabis co-use among African-American adolescents.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
- Prevalence of Nonmedical Use of Prescription Opioids and Association With Co-occurring Substance Use Disorders Among Adolescents in Substance Use Treatment.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018Article
- The genetic epidemiology of substance use disorder: A review.Drug and alcohol dependence · 2017Review
- Genetics of alcohol consumption in Drosophila melanogaster.Genes, brain, and behavior · 2017Article
- Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood.Journal of studies on alcohol and drugs · 2017Article
- Age of initiation and substance use progression: A multivariate latent growth analysis.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe investigated the etiological nature of comorbid alcohol, tobacco, and cannabis DSM-IV dependence symptoms in late adolescence and young adulthood while accounting for gender differences in the magnitude of genetic and environmental influences.
methodsUnivariate and multivariate twin modeling was used to determine the heritability of each substance and the etiology of multiple drug problems in a sample of 2484 registrants of the Center for Antisocial Drug Dependence who provided data at the second wave of an ongoing longitudinal study. We report on mean and prevalence levels of whole-life DSM-IV dependence symptoms that were assessed with the Composite International Diagnostic Interview-Substance Abuse Module. Biometrical analyses were limited to age-adjusted DSM-IV dependence symptom counts from a subset of twins that reported using alcohol, tobacco, or cannabis in their lifetime.
resultsMale and female alcohol, tobacco, and cannabis DSM-IV symptoms are indicators of a heritable unidimensional latent continuous trait. Additive genetic factors explain more than 60% of the common liability to drug dependence. A larger proportion of the variation in each substance is attributable to substance-specific genetic and environmental factors.
conclusionsThese data suggest that both common and substance-specific genetic and environmental factors contribute to individual differences in the levels of DSM-IV alcohol, tobacco, and cannabis dependence symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.