ArticleEuropean journal of oral sciences2011
Expression of kallikrein-related peptidase 4 in dental and non-dental tissues.
Article in European journal of oral sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- KLK12 Regulates MMP-1 and MMP-9 via Bradykinin Receptors: Biomarkers for Differentiating Latent and Active Bovine Tuberculosis.International journal of molecular sciences · 2022Article
- Odontogenesis-associated phosphoprotein truncation blocks ameloblast transition into maturation in OdaphScientific reports · 2021Article
- Article
- Mutations in RELT cause autosomal recessive amelogenesis imperfecta.Clinical genetics · 2019Article
- Enter the Dragon: The Dynamic and Multifunctional Evolution of Anguimorpha Lizard Venoms.Toxins · 2017Article
- TGF-β1 autocrine signalling and enamel matrix components.Scientific reports · 2016Article
- MMP20, KLK4, and MMP20/KLK4 double null mice define roles for matrix proteases during dental enamel formation.Molecular genetics & genomic medicine · 2016Article
- Fam83h null mice support a neomorphic mechanism for human ADHCAI.Molecular genetics & genomic medicine · 2016Article
- Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation.Molecular genetics & genomic medicine · 2015Article
- Fluoride affects enamel protein content via TGF-β1-mediated KLK4 inhibition.Journal of dental research · 2014Article
- Evolution of Klk4 and enamel maturation in eutherians.Biological chemistry · 2014Article
- Kallikrein-related peptidase-4 (KLK4): role in enamel formation and revelations from ablated mice.Frontiers in physiology · 2014Review
- M180 amelogenin processed by MMP20 is sufficient for decussating murine enamel.Journal of dental research · 2013Article
- Dental enamel development: proteinases and their enamel matrix substrates.ISRN dentistry · 2013Review
- BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.Nature cell biology · 2013Article
- Novel KLK4 and MMP20 mutations discovered by whole-exome sequencing.Journal of dental research · 2013Article
- Clinical significance of human kallikrein 12 gene expression in gastric cancer.World journal of gastroenterology · 2012Article
- A post-classical theory of enamel biomineralization… and why we need one.International journal of oral science · 2012Review
- Characterization of kallikrein-related peptidase 4 glycosylations.European journal of oral sciences · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Kallikrein-related peptidase 4 (KLK4) is critical for proper dental enamel formation. Klk4 null mice, and humans with two defective KLK4 alleles have obvious enamel defects, with no other apparent phenotype. KLK4 mRNA or protein is reported to be present in tissues besides teeth, including prostate, ovary, kidney, liver, and salivary gland. In this study we used the Klk4 knockout/NLS-lacZ knockin mouse to assay Klk4 expression using β-galactosidase histochemistry. Incubations for 5 h were used to detect KLK4 expression with minimal endogenous background, while overnight incubations susceptible to false positives were used to look for trace KLK4 expression. Developing maxillary molars at postnatal days 5, 6, 7, 8, and 14, developing mandibular incisors at postnatal day 14, and selected non-dental tissues from adult wild-type and Klk4(lacZ/lacZ) mice were examined by X-gal histochemistry. After 5 h of incubation, X-gal staining was observed specifically in the nuclei of maturation-stage ameloblasts in molars and incisors from Klk4(lacZ/lacZ) mice and was detected weakly in the nuclei of salivary gland ducts and in patches of prostate epithelia. We conclude that KLK4 is predominantly a tooth-specific protease with low expression in submandibular salivary gland and prostate, and with no detectable expression in liver, kidney, testis, ovary, oviduct, epididymis, and vas deferens.
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Registered trials
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