ArticlePloS one2012
GABA expression and regulation by sensory experience in the developing visual system.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Ototoxicity-related changes in GABA immunolabeling within the rat inferior colliculus.Hearing research · 2024Article
- Epigenetic regulation of GABAergic differentiation in the developing brain.Frontiers in cellular neuroscience · 2022Article
- Posterior brain sensorimotor recruitment for inhibition of delayed responses in children.Experimental brain research · 2021Article
- An Innate Color Preference Displayed byFrontiers in behavioral neuroscience · 2020Article
- Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing.Developmental neurobiology · 2018Article
- Direct intertectal inputs are an integral component of the bilateral sensorimotor circuit for behavior in Xenopus tadpoles.Journal of neurophysiology · 2018Article
- Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system.The Journal of experimental biology · 2017Article
- Experience-dependent plasticity of excitatory and inhibitory intertectal inputs in Xenopus tadpoles.Journal of neurophysiology · 2016Article
- Article
- Article
- A population of gap junction-coupled neurons drives recurrent network activity in a developing visual circuit.Journal of neurophysiology · 2016Article
- The horizontal brain slice preparation: a novel approach for visualizing and recording from all layers of the tadpole tectum.Journal of neurophysiology · 2015Article
- The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice.PloS one · 2014Article
- Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.Disease models & mechanisms · 2013Review
- Global hyper-synchronous spontaneous activity in the developing optic tectum.Scientific reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The developing retinotectal system of the Xenopus laevis tadpole is a model of choice for studying visual experience-dependent circuit maturation in the intact animal. The neurotransmitter gamma-aminobutyric acid (GABA) has been shown to play a critical role in the formation of sensory circuits in this preparation, however a comprehensive neuroanatomical study of GABAergic cell distribution in the developing tadpole has not been conducted. We report a detailed description of the spatial expression of GABA immunoreactivity in the Xenopus laevis tadpole brain at two key developmental stages: stage 40/42 around the onset of retinotectal innervation and stage 47 when the retinotectal circuit supports visually-guided behavior. During this period, GABAergic neurons within specific brain structures appeared to redistribute from clusters of neuronal somata to a sparser, more uniform distribution. Furthermore, we found that GABA levels were regulated by recent sensory experience. Both ELISA measurements of GABA concentration and quantitative analysis of GABA immunoreactivity in tissue sections from the optic tectum show that GABA increased in response to a 4 hr period of enhanced visual stimulation in stage 47 tadpoles. These observations reveal a remarkable degree of adaptability of GABAergic neurons in the developing brain, consistent with their key contributions to circuit development and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.