ArticleAdvances in pharmacological sciences2011
Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind study.
Article in Advances in pharmacological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Effects of Vitamin C and/or E Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: A Systematic Review and Subgroup Meta-analysis.Nutrition reviews · 2026Pooled it
- Research Progress on the Relationship between Vitamins and Diabetes: Systematic Review.International journal of molecular sciences · 2023Pooled it
- Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials.European journal of clinical nutrition · 2017Pooled it
- A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular adhesion molecules in type 2 diabetes mellitus.European journal of clinical nutrition · 2019Trial
- Trial
- Combined effect of metformin with ascorbic acid versus acetyl salicylic acid on diabetes-related cardiovascular complication; a 12-month single blind multicenter randomized control trial.Cardiovascular diabetology · 2017 · on this mapTrial
- Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial.Drug design, development and therapy · 2015Trial
- Article
- Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin.Physiological research · 2026Article
- Vitamin C intake is a novel potential therapeutic approach in the secretion of adiponectin and in the treatment of abdominal obesity.Caspian journal of internal medicine · 2026Article
- The mechanistic interplay of reactive oxygen species in metabolic pathways and insulin signaling in type 2 diabetes.Molecular biology reports · 2025Review
- Gallic Acid and Vitamin C Mitigate Histopathological Changes in the Retina by Attenuating Dyslipidemia and Mitigating Oxidative Stress, Inflammation, and Apoptosis in the Eyes of Type 2 Diabetic Rats Induced With Fructose/Streptozotocin.Food science & nutrition · 2025Article
- Determination of the Precision of Glucometers Used in Saudi Arabia.Sensors (Basel, Switzerland) · 2025Article
- The association between type 2 diabetes and dietary antioxidant index: a cross-sectional study in the Iranian population.Archives of endocrinology and metabolism · 2025Article
- Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review.Journal of advanced research · 2025Review
- Immediate effects of passion fruit juice supplementation on working ability and attention in healthy participants.Current research in physiology · 2024Article
- Resveratrol Modulates Chemosensitisation to 5-FU via β1-Integrin/HIF-1α Axis in CRC Tumor Microenvironment.International journal of molecular sciences · 2023Article
- Vitamin C status and its change in relation to glucose-lipid metabolism in overweight and obesity patients following laparoscopic sleeve gastrectomy.European journal of clinical nutrition · 2022Article
- Prospective dietary radical scavengers: Boon in Pharmacokinetics, overcome insulin obstruction via signaling cascade for absorption during impediments in metabolic disorder like Diabetic Mellitus.Journal of diabetes and metabolic disorders · 2022Review
- Effects of Chronic Arginase Inhibition with Norvaline on Tau Pathology and Brain Glucose Metabolism in Alzheimer's Disease Mice.Neurochemical research · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
No study has ever examined the effect of vitamin C with metformin on fasting (FBS) and postmeal blood glucose (PMBG) as well as glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). The goal was to examine the effect of oral vitamin C with metformin on FBS, PMBG, HbA1c, and plasma ascorbic acid level (PAA) with type 2 DM. Seventy patients with type 2 DM participated in a prospective, double-blind, placebo-controlled, 12-week study. The patients with type 2 DM were divided randomly into placebo and vitamin C group of 35 each. Both groups received the treatment for twelve weeks. Decreased PAA levels were found in patients with type 2 diabetes mellitus. This level was reversed significantly after treatment with vitamin C along with metformin compared to placebo with metformin. FBS, PMBG, and HbA1c levels showed significant improvement after 12 weeks of treatment with vitamin C. In conclusion, oral supplementation of vitamin C with metformin reverses ascorbic acid levels, reduces FBS, PMBG, and improves HbA1c. Hence, both the drugs in combination may be used in the treatment of type 2 DM to maintain good glycemic control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.