ArticlePLoS pathogens2012
(Homo)glutathione deficiency impairs root-knot nematode development in Medicago truncatula.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Transcriptome and Co-Expression Network Analyses of Resistant and Susceptible Rice Cultivars in Response toInternational journal of molecular sciences · 2025Article
- Article
- Metabolome and Transcriptome Profiling Reveals the Function of MdSYP121 in the Apple Response toInternational journal of molecular sciences · 2023Article
- AtSWEET1 negatively regulates plant susceptibility to root-knot nematode disease.Frontiers in plant science · 2023Article
- The Different Metabolic Responses of Resistant and Susceptible Wheats toMetabolites · 2022Article
- The Regulation of Pea (Frontiers in plant science · 2022Article
- Metabolic Analysis of the Development of the Plant-Parasitic Cyst NematodesInternational journal of molecular sciences · 2021Article
- Identification of the Complex Interplay Between Nematode-Related lncRNAs and Their Target Genes inFrontiers in plant science · 2021Article
- Modulation of (Homo)Glutathione Metabolism and HInternational journal of molecular sciences · 2020Article
- Biotechnological Perspectives of Omics and Genetic Engineering Methods in Alfalfa.Frontiers in plant science · 2020Review
- MicroRNAs, New Players in the Plant-Nematode Interaction.Frontiers in plant science · 2019Review
- The Synthesis and Role of β-Alanine in Plants.Frontiers in plant science · 2019Review
- Effector gene birth in plant parasitic nematodes: Neofunctionalization of a housekeeping glutathione synthetase gene.PLoS genetics · 2018Article
- Novel global effector mining from the transcriptome of early life stages of the soybean cyst nematode Heterodera glycines.Scientific reports · 2018Article
- Differential Metabolic Profiles during the Developmental Stages of Plant-Parasitic Nematode Meloidogyne incognita.International journal of molecular sciences · 2017Article
- Article
- The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode.Genome biology · 2014Article
- Altered sucrose synthase and invertase expression affects the local and systemic sugar metabolism of nematode-infected Arabidopsis thaliana plants.Journal of experimental botany · 2014Article
- On the track of transfer cell formation by specialized plant-parasitic nematodes.Frontiers in plant science · 2014Review
- Functional analysis of Arabidopsis mutants points to novel roles for glutathione in coupling H(2)O(2) to activation of salicylic acid accumulation and signaling.Antioxidants & redox signaling · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root-knot nematodes (RKN) are obligatory plant parasitic worms that establish and maintain an intimate relationship with their host plants. During a compatible interaction, RKN induce the redifferentiation of root cells into multinucleate and hypertrophied giant cells essential for nematode growth and reproduction. These metabolically active feeding cells constitute the exclusive source of nutrients for the nematode. Detailed analysis of glutathione (GSH) and homoglutathione (hGSH) metabolism demonstrated the importance of these compounds for the success of nematode infection in Medicago truncatula. We reported quantification of GSH and hGSH and gene expression analysis showing that (h)GSH metabolism in neoformed gall organs differs from that in uninfected roots. Depletion of (h)GSH content impaired nematode egg mass formation and modified the sex ratio. In addition, gene expression and metabolomic analyses showed a substantial modification of starch and γ-aminobutyrate metabolism and of malate and glucose content in (h)GSH-depleted galls. Interestingly, these modifications did not occur in (h)GSH-depleted roots. These various results suggest that (h)GSH have a key role in the regulation of giant cell metabolism. The discovery of these specific plant regulatory elements could lead to the development of new pest management strategies against nematodes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.