ArticlePLoS computational biology2012
Short conduction delays cause inhibition rather than excitation to favor synchrony in hybrid neuronal networks of the entorhinal cortex.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex.Current research in neurobiology · 2024Review
- Automatic Adaptation of Model Neurons and Connections to Build Hybrid Circuits with Living Networks.Neuroinformatics · 2020Article
- Macroscopic phase resetting-curves determine oscillatory coherence and signal transfer in inter-coupled neural circuits.PLoS computational biology · 2019Article
- Phase response theory explains cluster formation in sparsely but strongly connected inhibitory neural networks and effects of jitter due to sparse connectivity.Journal of neurophysiology · 2019Article
- RTHybrid: A Standardized and Open-Source Real-Time Software Model Library for Experimental Neuroscience.Frontiers in neuroinformatics · 2019Article
- Globally attracting synchrony in a network of oscillators with all-to-all inhibitory pulse coupling.Physical review. E · 2017Article
- Unitary synaptic connections among substantia nigra pars reticulata neurons.Journal of neurophysiology · 2016Article
- Stimulus-dependent synchronization in delayed-coupled neuronal networks.Scientific reports · 2016Article
- Slow noise in the period of a biological oscillator underlies gradual trends and abrupt transitions in phasic relationships in hybrid neural networks.PLoS computational biology · 2014Article
- The past, present, and future of real-time control in cellular electrophysiology.IEEE transactions on bio-medical engineering · 2014Review
- Synchronization of delayed coupled neurons in presence of inhomogeneity.Journal of computational neuroscience · 2014Article
- Intercellular delay regulates the collective period of repressively coupled gene regulatory oscillator networks.IEEE transactions on automatic control · 2014Article
- Effects of synaptic plasticity on phase and period locking in a network of two oscillatory neurons.Journal of mathematical neuroscience · 2014Article
- Hippocampal CA1 pyramidal neurons exhibit type 1 phase-response curves and type 1 excitability.Journal of neurophysiology · 2013Article
- Direct connections assist neurons to detect correlation in small amplitude noises.Frontiers in computational neuroscience · 2013Article
- Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit.Frontiers in neural circuits · 2013Article
- Effect of phase response curve skew on synchronization with and without conduction delays.Frontiers in neural circuits · 2013Article
- Controlling the oscillation phase through precisely timed closed-loop optogenetic stimulation: a computational study.Frontiers in neural circuits · 2013Article
- Impact of adaptation currents on synchronization of coupled exponential integrate-and-fire neurons.PLoS computational biology · 2012Article
- When Long-Range Zero-Lag Synchronization is Feasible in Cortical Networks.Frontiers in computational neuroscience · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
How stable synchrony in neuronal networks is sustained in the presence of conduction delays is an open question. The Dynamic Clamp was used to measure phase resetting curves (PRCs) for entorhinal cortical cells, and then to construct networks of two such neurons. PRCs were in general Type I (all advances or all delays) or weakly type II with a small region at early phases with the opposite type of resetting. We used previously developed theoretical methods based on PRCs under the assumption of pulsatile coupling to predict the delays that synchronize these hybrid circuits. For excitatory coupling, synchrony was predicted and observed only with no delay and for delays greater than half a network period that cause each neuron to receive an input late in its firing cycle and almost immediately fire an action potential. Synchronization for these long delays was surprisingly tight and robust to the noise and heterogeneity inherent in a biological system. In contrast to excitatory coupling, inhibitory coupling led to antiphase for no delay, very short delays and delays close to a network period, but to near-synchrony for a wide range of relatively short delays. PRC-based methods show that conduction delays can stabilize synchrony in several ways, including neutralizing a discontinuity introduced by strong inhibition, favoring synchrony in the case of noisy bistability, and avoiding an initial destabilizing region of a weakly type II PRC. PRCs can identify optimal conduction delays favoring synchronization at a given frequency, and also predict robustness to noise and heterogeneity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.