ArticleDevelopment (Cambridge, England)2012
Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Neuronal CDK5RAP3 deficiency leads to encephalo-dysplasia via upregulation of N-glycosylases and glycogen deposition.Cell death discovery · 2025Article
- Origin, identity, and function of terminal Schwann cells.Trends in neurosciences · 2024Review
- The structure of sensory afferent compartments in health and disease.Journal of anatomy · 2022Review
- Review
- Glutamic acid promotes hair growth in mice.Scientific reports · 2021Article
- Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Large-Scale Convergence of Receptor Cell Arrays Onto Afferent Terminal Arbors in the Lorenzinian Electroreceptors ofFrontiers in neuroanatomy · 2020Article
- Developing a sense of touch.Development (Cambridge, England) · 2017Review
- Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.Pain reports · 2016Article
- Synaptic-like vesicles and candidate transduction channels in mechanosensory terminals.Journal of anatomy · 2015Review
- Hair follicle bulge cultures yield class III β-tubulin-positive melanoglial cells.Histochemistry and cell biology · 2015Article
- Mechanotransduction in the muscle spindle.Pflugers Archiv : European journal of physiology · 2015Review
- Diversification and specialization of touch receptors in skin.Cold Spring Harbor perspectives in medicine · 2014Review
- Article
- The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles.eLife · 2014Article
- VGLUTs in Peripheral Neurons and the Spinal Cord: Time for a Review.ISRN neurology · 2013Review
- The sensory neurons of touch.Neuron · 2013Review
- The anatomy, function, and development of mammalian Aβ low-threshold mechanoreceptors.Frontiers in biology · 2013Article
- Glutamatergic modulation of synaptic-like vesicle recycling in mechanosensory lanceolate nerve terminals of mammalian hair follicles.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The piloneural collar in mammalian hairy skin comprises an intricate pattern of circumferential and longitudinal sensory afferents that innervate primary and secondary pelage hairs. The longitudinal afferents tightly associate with terminal Schwann cell processes to form encapsulated lanceolate nerve endings of rapidly adapting mechanoreceptors. The molecular basis for piloneural development, maintenance and function is poorly understood. Here, we show that Nefh-expressing glutamatergic neurons represent a major population of longitudinal and circumferential sensory afferents innervating the piloneural collar. Our findings using a VGLUT2 conditional-null mouse model indicate that glutamate is essential for innervation, patterning and differentiation of NMDAR(+) terminal Schwann cells during piloneural collar development. Similarly, treatment of adult mice with a selective NMDAR antagonist severely perturbed piloneural collar structure and reduced excitability of these mechanosensory neurons. Collectively, these results show that DRG-derived glutamate is essential for the proper development, maintenance and sensory function of the piloneural mechanoreceptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.