ArticleJournal of magnetic resonance imaging : JMRI2012
Multi-modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis.
Article in Journal of magnetic resonance imaging : JMRI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Improving the lesion appearance on FLAIR images synthetized from quantitative MRI: a fast, hybrid approach.Magma (New York, N.Y.) · 2024Article
- Cortical microstructural involvement in cerebral small vessel disease.Cerebral circulation - cognition and behavior · 2024Article
- Article
- Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls.Magma (New York, N.Y.) · 2020Article
- Distribution of Cortical Diffusion Tensor Imaging Changes in Multiple Sclerosis.Frontiers in physiology · 2020Article
- Potential clinical impact of multiparametric quantitative MR spectroscopy in neurological disorders: A review and analysis.Magnetic resonance in medicine · 2020Review
- Multi-modal imaging with specialized sequences improves accuracy of the automated subcortical grey matter segmentation.Magnetic resonance imaging · 2019Article
- Quantitative Limbic System Mapping of Main Cognitive Domains in Multiple Sclerosis.Frontiers in neurology · 2018Article
- SyMRI of the Brain: Rapid Quantification of Relaxation Rates and Proton Density, With Synthetic MRI, Automatic Brain Segmentation, and Myelin Measurement.Investigative radiology · 2017Review
- The Role of T1-Weighted Derived Measures of Neurodegeneration for Assessing Disability Progression in Multiple Sclerosis.Frontiers in neurology · 2017Review
- Limbic Pathway Correlates of Cognitive Impairment in Multiple Sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2017Article
- Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituentNeuroImage. Clinical · 2017Article
- Brain imaging with synthetic MR in children: clinical quality assessment.Neuroradiology · 2016Article
- Lateral ventricular cerebrospinal fluid diffusivity as a potential neuroimaging marker of brain temperature in multiple sclerosis: a hypothesis and implications.Magnetic resonance imaging · 2015Article
- White matter segmentation based on a skeletonized atlas: effects on diffusion tensor imaging studies of regions of interest.Journal of magnetic resonance imaging : JMRI · 2014Article
- Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.Annals of clinical and translational neurology · 2014Article
- Multi-parametric representation of voxel-based quantitative magnetic resonance imaging.PloS one · 2014Article
- Article
- Automated measurement of the human corpus callosum using MRI.Frontiers in neuroinformatics · 2012Article
- Quantification of global cerebral atrophy in multiple sclerosis from 3T MRI using SPM: the role of misclassification errors.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the utility of multimodal quantitative MRI (qMRI) and atlas-based methods to identify characteristics of lesion-driven injury and neurodegeneration in relapsing remitting multiple sclerosis (RRMS). MATERIALS AND
methodsThis work is health insurance portability and accountability act compliant. High resolution T1-weighted, dual echo, and fluid-attenuated inversion recovery and diffusion tensor MRI images were prospectively acquired on 68 RRMS patients (range, 25-58 years) and 68 age-matched controls. The data were analyzed using standardized human brain atlas-based tissue segmentation procedures to obtain regional volumes and their corresponding T2 relaxation times and DTI maps.
resultsGroup-averaged brain atlas-based qMRI maps of T2, fractional anisotropy and diffusivities are visually presented and compared between controls and RRMS. The analysis shows a widespread injury in RRMS. Atrophy of the corpus callosum (CC) was substantial in RRMS. The qMRI attributes of the neocortex in combination with the CC such as T2 and diffusivities were elevated and correlated with disability.
conclusionUsing a standardized multimodal qMRI acquisition and analyses that accounted for lesion distribution we demonstrate that cerebral pathology is widespread in RRMS. Our analysis of CC and neocortex qMRI metrics in relation to disability points to a neurodegenerative injury component that is independent from lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.