ArticleHuman brain mapping2012
Disease and genetic contributions toward local tissue volume disturbances in schizophrenia: a tensor-based morphometry study.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.Human brain mapping · 2022Pooled it
- Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.Neuroscience and biobehavioral reviews · 2019Pooled it
- Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State.Schizophrenia bulletin · 2020Article
- Neural correlates of proactive and reactive aggression in adolescent twins.Aggressive behavior · 2017Article
- Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.Molecular psychiatry · 2016Article
- Frontal and striatal alterations associated with psychopathic traits in adolescents.Psychiatry research · 2015Article
- Hippocampal dysfunction during declarative memory encoding in schizophrenia and effects of genetic liability.Schizophrenia research · 2015Article
- Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer).Schizophrenia bulletin · 2015Article
- 48 echo T₂ myelin imaging of white matter in first-episode schizophrenia: evidence for aberrant myelination.NeuroImage. Clinical · 2014Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Structural brain deficits, especially frontotemporal volume reduction and ventricular enlargement, have been repeatedly reported in patients with schizophrenia. However, it remains unclear whether brain structural deformations may be attributable to disease-related or genetic factors. In this study, the structural magnetic resonance imaging data of 48 adult-onset schizophrenia patients, 65 first-degree nonpsychotic relatives of schizophrenia patients, 27 community comparison (CC) probands, and 73 CC relatives were examined using tensor-based morphometry (TBM) to isolate global and localized differences in tissue volume across the entire brain between groups. We found brain tissue contractions most prominently in frontal and temporal regions and expansions in the putamen/pallidum, and lateral and third ventricles in schizophrenia patients when compared with unrelated CC probands. Results were similar, though less prominent when patients were compared with their nonpsychotic relatives. Structural deformations observed in unaffected patient relatives compared to age-similar CC relatives were suggestive of schizophrenia-related genetic liability and were pronounced in the putamen/pallidum and medial temporal regions. Schizophrenia and genetic liability effects for the putamen/pallidum were confirmed by regions-of-interest analysis. In conclusion, TBM findings complement reports of frontal, temporal, and ventricular dysmorphology in schizophrenia and further indicate that putamen/pallidum enlargements, originally linked mainly with medication exposure in early studies, also reflect a genetic predisposition for schizophrenia. Thus, brain deformation profiles revealed in this study may help to clarify the role of specific genetic or environmental risk factors toward altered brain morphology in schizophrenia.
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