ArticleAJNR. American journal of neuroradiology2012
White matter alteration of the cingulum in Parkinson disease with and without dementia: evaluation by diffusion tensor tract-specific analysis.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease.Frontiers in neurology · 2021Pooled it
- Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- A quick test of cognitive speed can predict development of dementia in Parkinson's disease.Scientific reports · 2019Trial
- Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond.International journal of molecular sciences · 2024Review
- Serum glial cell line-derived neurotrophic factor: a potential biomarker for white matter alteration in Parkinson's disease with mild cognitive impairment.Frontiers in neuroscience · 2024Article
- White matter changes in Parkinson's disease.NPJ Parkinson's disease · 2023Review
- Automated three-dimensional major white matter bundle segmentation using diffusion magnetic resonance imaging.Anatomical science international · 2023Review
- Structural connectivity and brain network analyses in Parkinson's disease: A cross-sectional and longitudinal study.Frontiers in neurology · 2023Article
- Gray and white matter alterations in different predominant side and type of motor symptom in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Morphological basis of Parkinson disease-associated cognitive impairment: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Seed-Based Connectivity Prediction of Initial Outcome of Subthalamic Nuclei Deep Brain Stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- Magnetic Resonance Imaging Markers for Cognitive Impairment in Parkinson's Disease: Current View.Frontiers in aging neuroscience · 2022Review
- It Is Time to Study Overlapping Molecular and Circuit Pathophysiologies in Alzheimer's and Lewy Body Disease Spectra.Frontiers in systems neuroscience · 2021Review
- Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease.Journal of Parkinson's disease · 2021Article
- Neurocognitive and psychiatric disorders-related axonal degeneration in Parkinson's disease.Journal of neuroscience research · 2020Article
- Scan-rescan and inter-vendor reproducibility of neurite orientation dispersion and density imaging metrics.Neuroradiology · 2020Article
- CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Evaluation of white matter microstructure in patients with Parkinson's disease using microscopic fractional anisotropy.Neuroradiology · 2020Article
- Abnormal Cingulum Bundle Induced by Type 2 Diabetes Mellitus: A Diffusion Tensor Tractography Study.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIn PD, the neurodegenerative process begins in the brain stem and extends to the limbic system and finally into the cerebral cortex. We used diffusion tensor tractography to investigate the FA of the cingulate fiber tracts in patients with PD with and without dementia. MATERIALS AND
methodsFifteen patients with PD, 15 patients with PDD, and 15 age-matched healthy controls underwent diffusion tensor imaging with a 3T MR imager. Diffusion tensor tractography images of the anterior and posterior cingulate fiber tracts were generated. Mean diffusivity and FA were measured along the tractography of the anterior and posterior cingulate fiber tracts. One-way ANOVA with the Scheffé post hoc test was used to compare results among the groups.
resultsFA was significantly lower in patients with PDD than in healthy controls in both the anterior and the posterior cingulate fiber tracts (P = .003, P = .015) and significantly lower in patients with PD than in healthy controls (P = .003) in the anterior cingulate fiber tract. There were no significant mean diffusivity differences among the groups. MMSE and FA values of the anterior cingulate fiber tracts in patients with PDD were significantly correlated (r = 0.633, P < .05).
conclusionsThe reduced FA in patients with PD and PDD might reflect neuropathologic changes such as Lewy body pathology in the cingulate fibers. This abnormality might contribute to the dementing process in PD.
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