ArticleChemical communications (Cambridge, England)2012
Spontaneous inter-conversion of insulin fibril chirality.
Article in Chemical communications (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Peptide Conformational Determination With Vibrational Circular Dichroism and Isotope Labeling: Focused Review of 3Journal of peptide science : an official publication of the European Peptide Society · 2026Review
- Ultraviolet Raman Optical Activity as a Window Into Peptide Backbone Structure.Chembiochem : a European journal of chemical biology · 2026Article
- Fatty Acids Reverse the Supramolecular Chirality of Insulin Fibrils.The journal of physical chemistry letters · 2023Article
- Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1-42 aggregates.The FEBS journal · 2023Article
- Nanoscale imaging of individual amyloid aggregates extracted from brains of Alzheimer and Parkinson patients reveals presence of lipids in α-synuclein but not in amyloid βProtein science : a publication of the Protein Society · 2023Article
- Amyloid aggregates exert cell toxicity causing irreversible damages in the endoplasmic reticulum.Biochimica et biophysica acta. Molecular basis of disease · 2022Article
- Two Spectroscopies in One: Interference of Circular Dichroism and Raman Optical Activity.Angewandte Chemie (International ed. in English) · 2020Article
- A Tunable, Fullerene-Based Molecular Amplifier for Vibrational Circular Dichroism.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Article
- Instrumentation for Vibrational Circular Dichroism Spectroscopy: Method Comparison and Newer Developments.Molecules (Basel, Switzerland) · 2018Review
- Understanding amyloid fibril formation using protein fragments: structural investigations via vibrational spectroscopy and solid-state NMR.Biophysical reviews · 2018Review
- Ultraviolet Resonance Raman Spectroscopic Markers for Protein Structure and Dynamics.Trends in analytical chemistry : TRAC · 2018Article
- Formation and properties of amyloid fibrils of prion protein.Biophysical reviews · 2018Review
- Factors affecting the physical stability (aggregation) of peptide therapeutics.Interface focus · 2017Review
- Advances of Vibrational Circular Dichroism (VCD) in bioanalytical chemistry. A review.Analytica chimica acta · 2017Review
- Rapid Filament Supramolecular Chirality Reversal of HET-s (218-289) Prion Fibrils Driven by pH Elevation.The journal of physical chemistry. B · 2015Article
- pH-Driven Polymorphism of Insulin Amyloid-Like Fibrils.PloS one · 2015Article
- Amyloid fibrils: the eighth wonder of the world in protein folding and aggregation.Biophysical journal · 2014Article
- Is supramolecular filament chirality the underlying cause of major morphology differences in amyloid fibrils?Journal of the American Chemical Society · 2014Article
- Surface characterization of insulin protofilaments and fibril polymorphs using tip-enhanced Raman spectroscopy (TERS).Biophysical journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.