ReviewCurrent topics in behavioral neurosciences2012
Gene × environment interaction models in psychiatric genetics.
Review in Current topics in behavioral neurosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01809080 (Investigation Into the Interaction Between Genes and Stress in the Etiology of Depression in Interns), which is not on this map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation Into the Interaction Between Genes and Stress in the Etiology of Depression in Interns
Who cites it
8 citing papers in PubMed.
- Article
- Deep phenotyping as a contribution to personalized depression therapy: the GEParD and DaCFail protocols.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder.Alcohol, clinical & experimental research · 2023Article
- Review
- Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update.Current psychiatry reports · 2018Review
- Significance of risk polymorphisms for depression depends on stress exposure.Scientific reports · 2018Article
- Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis.Depression and anxiety · 2017Article
- Correcting systematic inflation in genetic association tests that consider interaction effects: application to a genome-wide association study of posttraumatic stress disorder.JAMA psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Gene-environment (G × E) interaction research is an emerging area in psychiatry, with the number of G × E studies growing rapidly in the past two decades. This article aims to give a comprehensive introduction to the field, with an emphasis on central theoretical and practical problems that are worth considering before conducting a G × E interaction study. On the theoretical side, we discuss two fundamental, but controversial questions about (1) the validity of statistical models for biological interaction and (2) the utility of G × E research for psychiatric genetics. On the practical side, we focus on study characteristics that potentially influence the outcome of G × E interaction studies and discuss strengths and pitfalls of different study designs, including recent approaches like Genome-Environment Wide Interaction Studies (GEWIS). Finally, we discuss recent developments in G × E interaction research on the most heavily investigated example in psychiatric genetics, the interaction between a serotonin transporter gene promoter variant (5-HTTLPR) and stress on depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.