ReviewCurrent opinion in HIV and AIDS2012
Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.
Review in Current opinion in HIV and AIDS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Association of Epstein-Barr virus reactivation with the recovery of CD4/CD8 double-negative T lymphocytes after haploidentical hematopoietic stem cell transplantation.Bone marrow transplantation · 2017Trial
- Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis.Scientific reports · 2025Article
- Innate adaptive immune cell dynamics in tonsillar tissues during chronic SIV infection.Frontiers in immunology · 2023Article
- Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients.Frontiers in immunology · 2023Review
- Frequency and functional profile of circulating TCRαβBMC infectious diseases · 2022Article
- Double-negative T cells are increased in HIV-infected patients under antiretroviral therapy.Medicine · 2022Article
- Review
- Elevated Foxp3Frontiers in immunology · 2022Article
- Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions.Frontiers in immunology · 2021Article
- HIV Infection and Persistence in Pulmonary Mucosal Double Negative T CellsJournal of virology · 2020Article
- Comparative Analysis of Cellular Immune Responses in Conventional and SPF Olive Baboons (Comparative medicine · 2020Article
- Peripheral immune cell markers in children with recurrent respiratory infections in the absence of primary immunodeficiency.Experimental and therapeutic medicine · 2019Article
- Multivariate profiling of African green monkey and rhesus macaque T lymphocytes.Scientific reports · 2019Article
- Elevated peripheral blood B lymphocytes and CD3Oncology letters · 2018Article
- Elevated CD3PeerJ · 2018Article
- Low Double-Negative CD3Frontiers in immunology · 2016Article
- Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection.The Journal of general virology · 2015Review
- Immunogenetic characterization of a captive colony of sooty mangabeys (Cercocebus atys) used for SIV research.Journal of medical primatology · 2015Article
- Double negative (DN) αβ T cells: misperception and overdue recognition.Immunology and cell biology · 2015Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThis review summarizes the role of CD3+CD4-CD8- double-negative T cells, which have both regulatory and helper T-cell functions and may have the potential to compensate for the reduced levels of CD4 T cells during SIV/HIV infection. RECENT
findingsDouble-negative T cells have been characterized in several human diseases and in murine models of autoimmunity and transplantation, where they exhibit both immunoregulatory and helper T-cell-like function. During the natural nonpathogenic SIV infection of African nonhuman primates, the lack of clinical disease progression is associated with the presence of double-negative T cells that maintain helper T-cell functions while remaining refractory to viral infection. Moreover, DN T cells may compensate for very low levels of CD4+ T cells observed in a cohort of SIV-infected sooty mangabeys that have remained free of clinical AIDS for over 10 years. These studies identify a potential for double-negative T cells to provide critical helper function during HIV infection. SUMMARY: Double-negative T cells with some CD4+ T-cell functions are associated with a nonpathogenic outcome during SIV infection and represent a potential immune therapeutic target in HIV-infected patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.