Evidence map›Paper›PMID 22240460›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2012

Trends in reasons for hospitalization in a multisite United States cohort of persons living with HIV, 2001-2008.

Stephen A Berry, John A Fleishman, Richard D Moore, Kelly A Gebo, HIV Research Network

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Guideline
  2. A Randomized Trial to Test a Peer Mentor Intervention to Improve Outcomes in Persons Hospitalized With HIV Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Trial
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  9. Article
  10. Sequelae of Immunocompromised Host Pneumonia.Clinics in chest medicine · 2025
    Review
  11. Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stephen A BerryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sberry8@jhmi.edu
John A Fleishman
Richard D Moore
Kelly A Gebo
HIV Research Network
Johns Hopkins University · USAgency for Healthcare Research and Quality · US

Funding

North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
HIV DISEASE OUTCOMES IN DRUG USERS IN CLINICAL PRACTICER01DA011602 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 1998 to 2013
$10.8M
MID CAREER INVESTIGATOR AWARDK24DA000432 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2000 to 2009
$1.5M
Alcohol and HIV Treatment and Clinical ProgressionR01AA016893 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2008 to 2011
$1.3M
Universal Screening of HIV-Infected Persons for Gonorrhea and ChlamydiaK23AI084854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BERRY, STEPHEN ARTHUR · 2010 to 2014
$671k
CLINICAL OUTCOMES IN ELDERLY HIV PATIENTSR01AG026250 · NIA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2006 to 2007
$197k
NIAAA NIH HHS R01 AA016893NIAAA NIH HHS R01 AA16893NIAID NIH HHS K23 AI084854NIAID NIH HHS K23AI084854NIAID NIH HHS U01 AI069918NIA NIH HHS R01 AG026250NIDA NIH HHS K24 DA000432NIDA NIH HHS K24 DA00432NIDA NIH HHS R01 DA011602PHS HHS 290-01-0012
6 · The paper itself

Abstract

introductionHospitalization rates for comorbid conditions among persons living with HIV in the current highly active antiretroviral therapy era are unknown.

methodsHospitalization data from 2001 to 2008 were obtained on 11,645 adults receiving longitudinal HIV care at 4 geographically diverse US HIV clinics within the HIV Research Network. Modified clinical classification software from the Agency for Healthcare Research and Quality assigned primary ICD-9 codes into diagnostic categories. Analysis was performed with repeated measures negative binomial regression.

resultsDuring 2001 to 2008, the rate of AIDS-defining illness (ADI) hospitalizations declined from 6.7 to 2.7 per 100 person-years, incidence rate ratio per year, 0.89 (0.87, 0.91). Among the other diagnostic categories with average rates >2 per 100 person-years, cardiovascular hospitalizations increased over time [1.07 (1.03, 1.11)], whereas non-AIDS-defining infection [0.98 (0.96, 1.00)], psychiatric [0.96 (0.93, 1.00)], and gastrointestinal/liver [0.96 (0.92, 1.00)] were slightly decreasing or stable. Although less frequent overall, renal and pulmonary admissions also increased over time in univariate and multivariate analyses. Of all diagnostic categories, ADI admissions had the longest mean length of stay, 10.5 days. DISCUSSION: ADI hospitalizations have continued to decline in recent years but are still relatively frequent and potentially costly given long lengths of stay. Increases or stability in the rates of chronic end-organ disease admissions imply a need for broader medical knowledge among individual clinicians and/or teams who care for persons living with HIV and a need for long-term access to medications for these conditions.

Indexed as

AdolescentAdultAIDS-Related Opportunistic InfectionsCohort StudiesComorbidityFemaleHIV InfectionsHospitalizationHumansLength of StayLongitudinal StudiesMaleMiddle AgedUnited StatesYoung Adult

Identifiers

PMID22240460
PMCPMC3299935
OpenAlexW1993545874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.