Evidence map›Paper›PMID 22240162›Full record

ReviewThe FEBS journal2012

Outer membrane protein A and OprF: versatile roles in Gram-negative bacterial infections.

Subramanian Krishnan, Nemani V Prasadarao

Open access · bronzeAbstract readReview
In one paragraph

Review in The FEBS journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 129 citations in OpenAlex.

  1. Role of cell-associated and secretion-independent virulence factors of Pseudomonas aeruginosa in microbial keratitis and anti-virulence therapeutic strategies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
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  11. Unveiling the impact ofInfection and immunity · 2024
    Article
  12. Development and utilization ofbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Immunodominant extracellular loops ofbioRxiv : the preprint server for biology · 2024
    Article
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  19. Diagnosis of extraintestinal pathogenicCurrent research in microbial sciences · 2024
    Review
  20. Evaluation of novel compounds as anti-bacterial or anti-virulence agents.Frontiers in cellular and infection microbiology · 2024
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Subramanian KrishnanDivision of Infectious Diseases, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, CA, USA.
Nemani V Prasadarao
Children's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

Brain Endothelial Receptor for E. coliR01AI040567 · NIAID · CHILDREN'S HOSPITAL OF LOS ANGELES · PI DAVIS, MARK E, GODDARD, WILLIAM ANDREW · 2001 to 2015
$5.5M
Maneuvering of Macrophage Function By Escherichia coli K1R01NS073115 · NINDS · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NEMANI, PRASADARAO V · 2010 to 2014
$1.6M
Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease ProgressionR21AI073115 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAIRAM RAO · 2007 to 2008
$426k
BRAIN ENDOTHELIAL GLYCOPROTEIN INTERACTIVE WITH E COLIR29AI040567 · NIAID · CHILDREN'S HOSPITAL LOS ANGELES · PI NEMANI, PRASADARAO V · 1997 to 2001
$211k
Role of Complement Proteins in E. coli MeningitisR03HD041525 · NICHD · CHILDREN'S HOSPITAL LOS ANGELES · PI NEMANI, PRASADARAO V · 2002 to 2003
$150k
NIAID NIH HHS AI40567NIAID NIH HHS AI73115NIAID NIH HHS R01 AI040567NIAID NIH HHS R21 AI073115NIAID NIH HHS R29 AI040567NICHD NIH HHS HD41525NICHD NIH HHS R03 HD041525NINDS NIH HHS R01 NS073115
6 · The paper itself

Abstract

Outer membrane protein A (OmpA) is an abundant protein of Escherichia coli and other enterobacteria and has a multitude of functions. Although the structural features and porin function of OmpA have been well studied, its role in the pathogenesis of various bacterial infections has emerged only during the last decade. The four extracellular loops of OmpA interact with a variety of host tissues for adhesion to and invasion of the cell and for evasion of host-defense mechanisms when inside the cell. This review describes how various regions present in the extracellular loops of OmpA contribute to the pathogenesis of neonatal meningitis induced by E. coli K1 and to many other functions. In addition, the function of OmpA-like proteins, such as OprF of Pseudomonas aeruginosa, is discussed.

Indexed as

Amino Acid SequenceBacterial Outer Membrane ProteinsBacterial ProteinsEndothelial CellsEscherichia coliGram-Negative Bacterial InfectionsMolecular Sequence DataSequence AlignmentBacterial Outer Membrane ProteinsBacterial ProteinsOMPA outer membrane proteinsOprF protein, Pseudomonas aeruginosa

Identifiers

PMID22240162
PMCPMC3338869
OpenAlexW1496063460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.