ArticleJournal of the American Chemical Society2012
Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- The role of transmembrane proton transport rates in mild mitochondrial uncoupling by arylamide substituted fatty acids.Chemical science · 2026Article
- Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer's Disease: An Educational Literature Review.Molecular neurobiology · 2025Review
- Bioorthogonal Chemistry in Cellular Organelles.Topics in current chemistry (Cham) · 2023Review
- Novel Strategies in the Early Detection and Treatment of Endothelial Cell-Specific Mitochondrial Dysfunction in Coronary Artery Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Synthesis of a fluorinated pyronin that enables blue light to rapidly depolarize mitochondria.RSC medicinal chemistry · 2022Article
- A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons.Cellular and molecular life sciences : CMLS · 2022Article
- Mitochondrial Dysfunction in Alzheimer's Disease: Opportunities for Drug Development.Current neuropharmacology · 2022Article
- AlkylRSC chemical biology · 2021Article
- Energy metabolism design of the striated muscle cell.Physiological reviews · 2021Review
- Exporting Metal-Carbene Chemistry to Live Mammalian Cells: Copper-Catalyzed Intracellular Synthesis of Quinoxalines Enabled by N-H Carbene Insertions.Angewandte Chemie (International ed. in English) · 2021Article
- Exploring the therapeutic potential of mitochondrial uncouplers in cancer.Molecular metabolism · 2021Review
- Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Mitochondrial light switches: optogenetic approaches to control metabolism.The FEBS journal · 2020Review
- TPP-based mitocans: a potent strategy for anticancer drug design.RSC medicinal chemistry · 2020Review
- Label-free chlorine and nitrogen-doped fluorescent carbon dots for target imaging of lysosomes in living cells.Mikrochimica acta · 2020Article
- Tetrazine as a general phototrigger to turn on fluorophores.Chemical science · 2020Article
- An Oncometabolite Isomer Rapidly Induces a Pathophysiological Protein Modification.ACS chemical biology · 2020Article
- Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance.EMBO reports · 2020Article
- Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress.Biomolecules · 2020Review
- Protein Spin Labeling with a Photocaged Nitroxide Using Diels-Alder Chemistry.Chembiochem : a European journal of chemical biology · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.