ArticleAnalytical chemistry2012
Multinode acoustic focusing for parallel flow cytometry.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.Lab on a chip · 2026Review
- Essential Fluidics for a Flow Cytometer.Current protocols · 2024Article
- Raman Flow Cytometry and Its Biomedical Applications.Biosensors · 2024Review
- Article
- Processes for the 3D Printing of Hydrodynamic Flow-Focusing Devices.Micromachines · 2023Article
- Flow cytometry and cell sorting.Frontiers in medicine · 2023Review
- High-Throughput Parallel Optofluidic 3D-Imaging Flow Cytometry.Small science · 2022Article
- Ultrasonic Particle Manipulation in Glass Capillaries: A Concise Review.Micromachines · 2021Review
- Extremely High-Throughput Parallel Microfluidic Vortex-Actuated Cell Sorting.Micromachines · 2021Article
- Acoustic Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020Review
- A deep learning approach for designed diffraction-based acoustic patterning in microchannels.Scientific reports · 2020Article
- Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches.International journal of molecular sciences · 2020Review
- Cell alignment and accumulation using acoustic nozzle for bioprinting.Scientific reports · 2019Article
- Single-cell technologies in reproductive immunology.American journal of reproductive immunology (New York, N.Y. : 1989) · 2019Review
- Design, modeling, and experimental validation of an acoustofluidic platform for nanoscale molecular synthesis and detection.Physics of fluids (Woodbury, N.Y. : 1994) · 2019Article
- Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.Royal Society open science · 2019Article
- Applications of Acoustofluidics in Bioanalytical Chemistry.Analytical chemistry · 2019Article
- Acoustofluidic separation of cells and particles.Microsystems & nanoengineering · 2019Article
- Cell Cytometry: Review and Perspective on Biotechnological Advances.Frontiers in bioengineering and biotechnology · 2019Review
- Separation of sub-micron particles from micron particles using acoustic fluid relocation combined with acoustophoresis.Analytical and bioanalytical chemistry · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Flow cytometry can simultaneously measure and analyze multiple properties of single cells or particles with high sensitivity and precision. Yet, conventional flow cytometers have fundamental limitations with regards to analyzing particles larger than about 70 μm, analyzing at flow rates greater than a few hundred microliters per minute, and providing analysis rates greater than 50,000 per second. To overcome these limits, we have developed multinode acoustic focusing flow cells that can position particles (as small as a red blood cell and as large as 107 μm in diameter) into as many as 37 parallel flow streams. We demonstrate the potential of such flow cells for the development of high throughput, parallel flow cytometers by precision focusing of flow cytometry alignment microspheres, red blood cells, and the analysis of a CD4+ cellular immunophenotyping assay. This approach will have significant impact toward the creation of high throughput flow cytometers for rare cell detection applications (e.g., circulating tumor cells), applications requiring large particle analysis, and high volume flow cytometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.