ArticlePloS one2012
Chronic rejection pathology after orthotopic lung transplantation in mice: the development of a murine BOS model and its drawbacks.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Fibrotic progression from acute cellular rejection is dependent on secondary lymphoid organs in a mouse model of chronic lung allograft dysfunction.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study.Frontiers in immunology · 2024Article
- A Comprehensive Review on the Surgical Aspect of Lung Transplant Models in Mice and Rats.Cells · 2022Review
- Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome.Scientific reports · 2020Article
- An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.JCI insight · 2019Article
- The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation.Journal of cardiothoracic surgery · 2019Article
- Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection.Transplantation · 2018Review
- Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.JCI insight · 2017Review
- What makes a good pediatric transplant lung: Insights from in vivo lung morphometry with hyperpolarizedPediatric transplantation · 2017Article
- Update on Chronic Lung Allograft Dysfunction.Current transplantation reports · 2016Article
- Revascularization of the graft in obliterative bronchiolitis after heterotopic tracheal transplantation.Physiological reports · 2016Article
- CD4 T Cells but Not Th17 Cells Are Required for Mouse Lung Transplant Obliterative Bronchiolitis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
- Local origin of mesenchymal cells in a murine orthotopic lung transplantation model of bronchiolitis obliterans.The American journal of pathology · 2015Article
- CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients.American journal of respiratory cell and molecular biology · 2015Article
- Immune response to tissue-restricted self-antigens induces airway inflammation and fibrosis following murine lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Article
- Increased T cell glucose uptake reflects acute rejection in lung grafts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Ferret lung transplant: an orthotopic model of obliterative bronchiolitis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Complement activation is not required for obliterative airway disease induced by antibodies to major histocompatibility complex class I: Implications for chronic lung rejection.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2012Article
- T regulatory cells play a significant role in modulating MHC class I antibody-induced obliterative airway disease.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost all animal models for chronic rejection (CR) after lung transplantation (LTx) fail to resemble the human situation. It was our attempt to develop a representative model of CR in mice. Orthotopic LTx was performed in allografts receiving daily immunosuppression with steroids and cyclosporine. Controls included isografts and mice only undergoing thoracotomy (SHAM). Allografts were sacrificed 2, 4, 6, 8, 10 or 12 weeks after LTx. Pulmonary function was measured repeatedly in the 12w allografts, isografts and SHAM mice. Histologically, all allografts demonstrated acute rejection (AR) around the blood vessels and airways two weeks after LTx. This decreased to 50-75% up to 10 weeks and was absent after 12 weeks. Obliterative bronchiolitis (OB) lesions were observed in 25-50% of the mice from 4-12 weeks. Isografts and lungs of SHAM mice were normal after 12 weeks. Pulmonary function measurements showed a decline in FEV(0.1), TLC and compliance in the allografts postoperatively (2 weeks) with a slow recovery over time. After this initial decline, lung function of allografts increased more than in isografts and SHAM mice indicating that pulmonary function measurement is not a good tool to diagnose CR in a mouse. We conclude that a true model for CR, with clear OB lesions in about one third of the animals, but without a decline in lung function, is possible. This model is an important step forward in the development of an ideal model for CR which will open new perspectives in unraveling CR pathogenesis and exploring new treatment options.
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Registered trials
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