Trial reportPloS one2012
The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- A single dose of L-DOPA changes perceptual experiences and decreases latent inhibition in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Trial
- Dopaminergic Modulation of Decision Making and Subjective Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Article
- Rewarding properties of L-Dopa in experimental parkinsonism are mediated by sensitized dopamine D1 receptors in the dorsal striatum.Molecular psychiatry · 2025Article
- Behavioral and neurochemical interactions of the tricyclic antidepressant drug desipramine with L-DOPA in 6-OHDA-lesioned rats. Implications for motor and psychiatric functions in Parkinson's disease.Psychopharmacology · 2022Article
- Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It "Blowin' in the Wind"?Journal of personalized medicine · 2022Article
- Inpatient suicide in psychiatric settings: Evaluation of current prevention measures.Frontiers in psychiatry · 2022Review
- Revisiting positive affect and reward influences on cognitive control.Current opinion in behavioral sciences · 2021Article
- Soothing Your Heart and Feeling Connected: A New Experimental Paradigm to Study the Benefits of Self-Compassion.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
- Dopamine and addiction: what have we learned from 40 years of research.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Could the link between drug addiction in adulthood and substance use in adolescence result from a blurring of the boundaries between incentive and hedonic processes?Substance abuse and rehabilitation · 2019Review
- Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies.Journal of systems and integrative neuroscience · 2018Article
- Benefits and limitations of drug studies in temperament research: biochemical responses as indicators of temperament.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Evolving Concepts of Emotion and Motivation.Frontiers in psychology · 2018Review
- Inflammation Effects on Motivation and Motor Activity: Role of Dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Pleasure systems in the brain.Neuron · 2015Review
- Measuring anhedonia: impaired ability to pursue, experience, and learn about reward.Frontiers in psychology · 2015Review
- Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain.Frontiers in behavioral neuroscience · 2015Review
- What's deficient in reward deficiency?Journal of psychiatry & neuroscience : JPN · 2014Article
- A computational and neural model of momentary subjective well-being.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dopamine neurotransmission influences approach toward rewards and reward-related cues. The best cited interpretation of this effect proposes that dopamine mediates the pleasure that commonly accompanies reward. This hypothesis has received support in some animal models and a few studies in humans. However, direct assessments of the effect of transiently increasing dopamine neurotransmission have been largely limited to the use of psychostimulant drugs, which elevate brain levels of multiple neurotransmitters in addition to dopamine. In the present study we tested the effect of more selectively elevating dopamine neurotransmission, as produced by administration of the immediate dopamine precursor, L-DOPA (0, 100/25, 200/50 mg, Sinemet), in healthy human volunteers. Neither dose altered positive mood. The results suggest that dopamine neurotransmission does not directly influence positive mood in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.