SynthesisDeutsches Arzteblatt international2011
Acute traumatic coagulopathy in severe injury: incidence, risk stratification, and treatment options.
Synthesis in Deutsches Arzteblatt international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- [Complex pelvic traumas : data linkage of the German Pelvic Injury Register and the TraumaRegister DGU®].Der Unfallchirurg · 2015Pooled it
- Management of bleeding and coagulopathy following major trauma: an updated European guideline.Critical care (London, England) · 2013Pooled it
- Construction and preliminary trial test of a decision-making app for pre-hospital damage control resuscitation.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Major Risk Factors for Mortality in Elderly and Non-Elderly Adult Patients Emergently Admitted for Blunt Chest Wall Trauma: Hospital Length of Stay as an Independent Predictor.International journal of environmental research and public health · 2022Article
- Mechanism, frequency, transfusion and outcome of severe trauma in coagulopathic paediatric patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Plasmin drives burn-induced systemic inflammatory response syndrome.JCI insight · 2021Article
- Personalized modulation of coagulation factors using a thrombin dynamics model to treat trauma-induced coagulopathy.NPJ systems biology and applications · 2021Article
- Role of POC INR in the early stage of diagnosis of coagulopathy.Practical laboratory medicine · 2021Article
- Modern Management of Bleeding, Clotting, and Coagulopathy in Trauma Patients: What Is the Role of Viscoelastic Assays?Current trauma reports · 2020Article
- The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.Critical care (London, England) · 2019Article
- The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications.International journal of molecular sciences · 2017Review
- Prevalence and Associated Factors of Acute Traumatic Coagulopathy; a Cross Sectional Study.Emergency (Tehran, Iran) · 2017Article
- Hemodynamic Changes Following Routine Fluid Resuscitation in Patients With Blunt Trauma.Trauma monthly · 2016Article
- The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition.Critical care (London, England) · 2016Article
- Procoagulant and fibrinolytic activity after polytrauma in rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- [Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey].Der Unfallchirurg · 2015Article
- Effects of Intravenous Fluid Therapy on Clinical and Biochemical Parameters of Trauma Patients.Emergency (Tehran, Iran) · 2014Article
- International normalized ratio as a predictor of mortality in trauma patients in India.World journal of emergency medicine · 2014Article
- Clinical and mechanistic drivers of acute traumatic coagulopathy.The journal of trauma and acute care surgery · 2013Article
- The impact of arterial hypertension on polytrauma and traumatic brain injury.Deutsches Arzteblatt international · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical observation and research findings show that acute traumatic coagulopathy (ATC) is a major factor that must be addressed in the care of severely injured patients. In this review article, we discuss the incidence and causes of ATC, the potential means of early risk stratification for it, and recommendations for its treatment.
methodsWe selectively reviewed the pertinent literature and retrospectively analyzed data from the Trauma Registry of the German Trauma Society (Traumaregister der Deutschen Gesellschaft für Unfallchirurgie, TR-DGU) relating to the incidence, causes, and outcome of ATC. We provide an overview of current treatment recommendations, supplemented by our own findings regarding the ratio of packed red blood cell concentrate (pRBC) to fresh-frozen plasma (FFP) transfusion and regarding coagulation-factor-based treatments for coagulopathy in the acute phase after trauma. RESULTS AND
conclusionATC, a condition associated with increased morbidity and mortality, is seen on admission in one out of four patients with major trauma. The main causes of ATC are tissue damage, hypoperfusion, hemodilution, hypothermia, acidosis, and inflammation. It may be possible to identify patients at risk for ATC early on through the use of rapidly calculable, predictive numerical scales (McLaughlinScore, TASH, and ABC), laboratory tests, and imaging studies (FAST and CT). Acute treatment is focused on the control of bleeding and support of the coagulation system according to the current guidelines. Patients at high risk may benefit from a balanced transfusion strategy. Innovative strategies currently under study include point-of-care-guided treatment and coagulation-factor-concentrate-based treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.