ArticleBeilstein journal of organic chemistry2011
Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp.
Article in Beilstein journal of organic chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 57 citations in OpenAlex.
- Metabologenomic profiling of the endemic Australian fungusMycology · 2026Article
- Marine endophytes: biosynthetic engines for novel bioactive metabolites.Frontiers in microbiology · 2025Review
- Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.Marine drugs · 2024Review
- Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration.Heliyon · 2021Review
- Biological and Chemical Diversity of Marine Sponge-Derived Microorganisms over the Last Two Decades from 1998 to 2017.Molecules (Basel, Switzerland) · 2020Review
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine SpongeMarine drugs · 2019Article
- Unveiling Concealed Functions of Endosymbiotic Bacteria Harbored in the Ascomycete Stachylidium bicolor.Applied and environmental microbiology · 2018Article
- Production of hydroxy marilone C as a bioactive compound fromJournal, genetic engineering & biotechnology · 2016Article
- Recent progress in neuroactive marine natural products.Natural product reports · 2014Review
- Advances in the chemical analysis and biological activities of chuanxiong.Molecules (Basel, Switzerland) · 2012Review
- Antibacterial activity of halophilic bacterial bionts from marine invertebrates of mandapam-India.Indian journal of pharmaceutical sciences · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of three new phthalide derivatives, i.e., marilones A-C (1-3), and the known compound silvaticol (4). The skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique biochemical reactions considering fungal secondary metabolism. Marilone A (1) was found to have antiplasmodial activity against Plasmodium berghei liver stages with an IC(50) of 12.1 µM. Marilone B (2) showed selective antagonistic activity towards the serotonin receptor 5-HT(2B) with a K(i) value of 7.7 µM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.