ArticleThe Journal of infectious diseases2012
Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 78 citations in OpenAlex.
- Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Trial
- Trial
- Heavy metals and prevalence of sexually transmitted infections: a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2003-2016.BMC infectious diseases · 2026Article
- Current Evidence of Maternal Infection With Chlamydia trachomatis and Preeclampsia Risk.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution.Immunogenetics · 2024Article
- Epidemiology, Transmission Mode, and Pathogenesis ofAnimals : an open access journal from MDPI · 2024Review
- Review
- Functional interferon-epsilon gene polymorphisms and sexually transmitted infections of the endometrium.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Chlamydia trachomatis antigen induces TLR4-TAB1-mediated inflammation, but not cell death, in maternal decidua cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- The association of host genes with specific sexually transmitted infections.Frontiers in reproductive health · 2023Review
- Human genetic diversity regulating theHGG advances · 2022Article
- Genetic susceptibility loci forFrontiers in immunology · 2022Article
- Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control Strategy.Current issues in molecular biology · 2021Review
- Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Frontiers in immunology · 2021Review
- Article
- Association of variants in selected genes mediating host immune response with duration of Staphylococcus aureus bacteremia.Genes and immunity · 2020Article
- Genetic variations of NOD2 and MD2 genes in hepatitis B virus infection.Saudi journal of biological sciences · 2019Article
- Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.PloS one · 2019Article
- Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy.Memorias do Instituto Oswaldo Cruz · 2017Article
- Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease.Sexually transmitted diseases · 2017Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundToll-like receptors (TLRs) are involved in the innate immune response. We examined whether TLR variants are associated with Chlamydia trachomatis infection among women with pelvic inflammatory disease (PID).
methodsWe tested whether 18 tagging single nucleotide polymorphisms (tagSNPs) assayed in 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and 2 adaptor molecules (TIRAP, MyD88) were associated with C. trachomatis among 205 African American women with clinically suspected PID from the PID Evaluation and Clinical Health Study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). An empirical P value of <.004 was considered significant.
resultsWomen with PID who carried the TLR4 rs1927911 CC genotype had significantly increased odds of C. trachomatis (OR, 3.7; 95% CI, 1.6-8.8; P = .002). The TLR1 rs5743618TT genotype was also associated with C. trachomatis (OR, 2.8; 95% CI, 1.3-6.2; P = .008).
conclusionsAmong African American women with PID, variants in the TLR1 and TLR4 genes, which may increase signaling, were associated with increased C. trachomatis infection.
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Registered trials
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