Evidence map›Paper›PMID 22238227›Full record

ArticleCirculation2012

Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery.

Renato D Lopes, Rajendra H Mehta, Gail E Hafley, Judson B Williams, Michael J Mack, Eric D Peterson, Keith B Allen, Robert A Harrington, C Michael Gibson, Robert M Califf and 4 more

Registry-linked trialAbstract read
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In one paragraph

Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03217006 (Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts), which is not on this map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03217006 narecruitingnot on this mapstarted 2018, after this paper: background citation

Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: the ROMA Trial

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2018 to 2030Enrolled4,300ConditionsCoronary Artery Disease, Heart DiseasesArmsSingle arterial graft, Multiple arterial grafting
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  18. Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis.Molecular therapy. Methods & clinical development · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Renato D LopesDuke Clinical Research Institute, Duke University Medical Center, DUMC Box 3850, Durham, NC 27705, USA.
Rajendra H Mehta
Gail E Hafley
Judson B Williams
Michael J Mack
Eric D Peterson
Keith B Allen
Robert A Harrington
C Michael Gibson
Robert M Califf
Nicholas T Kouchoukos
T Bruce Ferguson
John H Alexander
Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) Investigators

Funding

Cardiothoracic Surgical Network Clinical CenterU01HL088953 · NHLBI · DUKE UNIVERSITY · PI SMITH, PETER K · 2007 to 2013
$2.6M
NHLBI NIH HHS U01 HL088953NHLBI NIH HHS U01-HL088953
6 · The paper itself

Abstract

backgroundVein graft failure (VGF) is common after coronary artery bypass graft surgery, but its relationship with long-term clinical outcomes is unknown. In this retrospective analysis, we examined the relationship between VGF, assessed by coronary angiography 12 to 18 months after coronary artery bypass graft surgery, and subsequent clinical outcomes. METHODS AND

resultsUsing the Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) trial database, we studied data from 1829 patients who underwent coronary artery bypass graft surgery and had an angiogram performed up to 18 months after surgery. The main outcome measure was death, myocardial infarction, and repeat revascularization through 4 years after angiography. VGF occurred in 787 of 1829 patients (43%). Clinical follow-up was completed in 97% of patients with angiographic follow-up. The composite of death, myocardial infarction, or revascularization occurred more frequently among patients who had any VGF compared with those who had none (adjusted hazard ratio, 1.58; 95% confidence interval, 1.21-2.06; P=0.008). This was due mainly to more frequent revascularization with no differences in death (adjusted hazard ratio, 1.04; 95% confidence interval, 0.71-1.52; P=0.85) or death or myocardial infarction (adjusted hazard ratio, 1.08; 95% confidence interval, 0.77-1.53; P=0.65).

conclusionsVGF is common after coronary artery bypass graft surgery and is associated with repeat revascularization but not with death and/or myocardial infarction. Further investigations are needed to evaluate therapies and strategies for decreasing VGF to improve outcomes in patients undergoing coronary artery bypass graft surgery.

Indexed as

Coronary Artery BypassAgedClinical Trials, Phase III as TopicCoronary AngiographyDouble-Blind MethodFemaleFollow-Up StudiesGraft Occlusion, VascularHumansMaleMiddle AgedMulticenter Studies as TopicMyocardial InfarctionProportional Hazards ModelsRandomized Controlled Trials as TopicRecurrence

Identifiers

PMID22238227
PMCPMC3699199

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.